Pharm Exam 2- Cholinergic Antagonists
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3 terms
Terms | Definitions |
|---|---|
 What are other names for cholinergic antagonists. Name depends on the receptor site- muscarinic or nicotinic | If at muscarinic receptor- Cholinergic antagonist - Parasympatholytic -Antimuscarinic Ex: Atropine and Scopolamine If at nicotinic site- Cholinergic antagonist -ganglionic blockers (autonomic NS) -Neuromuscular blockers (NMJ- Somatic) |
| Atropine | aka. Hyoscyamine (synthesized)- Reversible; Action: blocks muscarinic-R (prevents ACh binding) Blocks EXogenous agents > Endogenous agents (i.e. acetylecholine) Effect: varies with tissye type- most sensitive- salivary, bronchial, sweat glands |
| What Tissues Does AntiCholinergic Effect? | 1) CNS:Used to tx parkinsons (tremors)- benztropine; Tx motion sickness- scopolamine (s/e- drowsiness and amnesia; toxicity- CNS excitement, agitation, hallucinations)*atropine- minimal CNS effect 2) Eye:Blocks M3- pupil constriction∴ results in mydriasis. causes cycloplegia (lioss of accomodation); ↓ lacrimal secreation, ↓ outflow aqueous humor. ContraIndicated (CI) glaucoma Tx mydriasis and cycoplegia helpful in dilating eyes 3) CV System:low- 0.5mg atropine blocks M1 receptors; med-1-5mg blocks M2 receptors; toxic>10mg 4) Respiratory System: 5) GI Tract: 6) GU Tract: 7) Sweat glands: |
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