5 Written questions
5 Matching questions
- Pretest Probability
- Gausian Curve
- Approximately how many people does smoking kill in AL every year?
- Phases of Drug Development
- a Probability of disease in a patient with a positive test result PV+=true positive/(true positive + false positive) p. 39
- b The prevalence of disease in a specified group of subjects.
- c Normal distribution curve. based in statistical theory, describes the frequency distribution of repeated measurements of the same physical object by the same measurement.
- d 7,000
- e Phase 1: first stage of testing in humans (about 20-100 pple); small group of healthy volunteers; test for safety, tolerability, pharmokinetics, and pharmacodynamics
Phase 2: larger groups (about 20-300 ppl), assess how well the drug works, dosing requirments, efficacy
Phase 3: large groups (300-3,000 ppl), test to see how effective the drug is compared to other drugs
Phase 4: safety survellience, ongoing technical support
5 Multiple choice questions
- ARR (same as Attributable Risk), It is the absolute value of the control group event rate - the experimental group event rate.
- The more sensitive a test is, the better will be its NPV. The more specific a test it, the better will be its PPV.
- "degree to which the results of a study are correct for the sample of patients being studied...determined by how well the design, data collection, and analyses are carried out and..threatened by..biases and random variation" p. 10
- The fraction or proportion of a group of people initially free of the outcome of interest that develops the condition over a given period of time
- A general term for measures of association calculated from data in a 2x2 table. = Risk of disease in exposed (a/(a+b)) / Risk of disease in unexposed (c/(c+d))
5 True/False questions
Types of Prevention:
Secondary Prevention → Def: Reducing the impact of the disease
Ex. Rehabilitation for stroke
Relative Risk Reduction → How much of the risk is reduced in the experimental group compared with the control group. RRR=ARR/(rate of control group)
Dependent Variables → variables describing a possible effect p. 5
External Validity → "degree to which the results of a study are correct for the sample of patients being studied...determined by how well the design, data collection, and analyses are carried out and..threatened by..biases and random variation" p. 10
Epidemiology → "the study of disease occurrence in human populations" p. 3