5 Written Questions
5 Matching Questions
- Attributable Risk
- Approximately how many people live in the US?
- Phases of Drug Development
- Case Fatality Rate
- a Proportion of patients who die of a disease
- b Phase 1: first stage of testing in humans (about 20-100 pple); small group of healthy volunteers; test for safety, tolerability, pharmokinetics, and pharmacodynamics
Phase 2: larger groups (about 20-300 ppl), assess how well the drug works, dosing requirments, efficacy
Phase 3: large groups (300-3,000 ppl), test to see how effective the drug is compared to other drugs
Phase 4: safety survellience, ongoing technical support
- c ...300,000,000
- d a process at any stage of inference tending to produce results that depart systematically from true values.
- e The absolute difference in the rate of events between the control and the intervention group. ( same as ARR)
5 Multiple Choice Questions
- Def: Reducing the impact of the disease
Ex. Rehabilitation for stroke
- The more sensitive a test is, the better will be its NPV. The more specific a test it, the better will be its PPV.
- A general term for measures of association calculated from data in a 2x2 table. = Risk of disease in exposed (a/(a+b)) / Risk of disease in unexposed (c/(c+d))
- Def: Early detection of existing disease to reduce severity and complications
Ex. Screening for cancer
5 True/False Questions
Sensitivity → Proportion of people with a disease who have a positive test for the disease = true positives/(true positives + false negatives) p. 39
Cohort → Probability of disease in a patient with a positive test result PV+=true positive/(true positive + false positive) p. 39
Confounders → Patient characteristics that may affect the results a study it is trying to measure. They can decrease the validity of a study.
Specificity → Proportion of people with a disease who have a positive test for the disease = true positives/(true positives + false negatives) p. 39
PPV → a process at any stage of inference tending to produce results that depart systematically from true values.