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5 Written questions

5 Matching questions

  1. Pretest Probability
  2. Gausian Curve
  3. Approximately how many people does smoking kill in AL every year?
  4. PPV
  5. Phases of Drug Development
  1. a Probability of disease in a patient with a positive test result PV+=true positive/(true positive + false positive) p. 39
  2. b The prevalence of disease in a specified group of subjects.
  3. c Normal distribution curve. based in statistical theory, describes the frequency distribution of repeated measurements of the same physical object by the same measurement.
  4. d 7,000
  5. e Phase 1: first stage of testing in humans (about 20-100 pple); small group of healthy volunteers; test for safety, tolerability, pharmokinetics, and pharmacodynamics
    Phase 2: larger groups (about 20-300 ppl), assess how well the drug works, dosing requirments, efficacy
    Phase 3: large groups (300-3,000 ppl), test to see how effective the drug is compared to other drugs
    Phase 4: safety survellience, ongoing technical support

5 Multiple choice questions

  1. ARR (same as Attributable Risk), It is the absolute value of the control group event rate - the experimental group event rate.
  2. The more sensitive a test is, the better will be its NPV. The more specific a test it, the better will be its PPV.
  3. "degree to which the results of a study are correct for the sample of patients being studied...determined by how well the design, data collection, and analyses are carried out and..threatened by..biases and random variation" p. 10
  4. The fraction or proportion of a group of people initially free of the outcome of interest that develops the condition over a given period of time
  5. A general term for measures of association calculated from data in a 2x2 table. = Risk of disease in exposed (a/(a+b)) / Risk of disease in unexposed (c/(c+d))

5 True/False questions

  1. Types of Prevention:
    Secondary Prevention
    Def: Reducing the impact of the disease
    Ex. Rehabilitation for stroke

          

  2. Relative Risk ReductionHow much of the risk is reduced in the experimental group compared with the control group. RRR=ARR/(rate of control group)

          

  3. Dependent Variablesvariables describing a possible effect p. 5

          

  4. External Validity"degree to which the results of a study are correct for the sample of patients being studied...determined by how well the design, data collection, and analyses are carried out and..threatened by..biases and random variation" p. 10

          

  5. Epidemiology"the study of disease occurrence in human populations" p. 3

          

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