| Term | Definition |
|---|
| Retrovirus HIV | antiretrovirals developed specifically to limit progression of _____ |
| Acquired Immunodeficiency Syndrome Immune system | HIV causes ____ (AIDS), a dysfunction of the ______ |
| teenagers and women | Two of largest groups of new AIDS infections : |
| fast-tracked | HIV drugs are______ |
| Four | ____ classes of Antiretroviral drugs |
| Nucleoside reverse transcriptase inhibitors | NTRIs ( what does it stand for) bind and inhibit the action of the viral enzyme that facilitates the release of newly formed virus particles, preventing the spread of virus to health cells |
| zidovudine | Retrovir ( ) is an NRTI and is one of the 1st drugs developed for AIDS |
| didanosine advanced | Videx ( ) is an NRTI for _____ HIV in patients who can't tolerate AZT |
| lamivudine | Epivir ( ) is an NRTI for treatment of HIV with chronic Hep B |
| abacavir blood/brain barrier | Ziagen ( ) is able to penetrate the CNS ( ) is used when HIV penetrates the CNS |
| non-nucleoside reverse transcriptase inhibitors | NNRTIs ( what does it stand for ) are similar to NTRIs but inhibit the virus at a different rate |
| efavirenz | Sustiva ( ) is an NNRTI dosed once daily usually at bedtime |
| cleavage prolonged | Protease inhibitors (PIs) Prevent the ___ of certain HIV protein precursors which are needed for replication of new viral cells. Protease Inhibitors have ____ survival among AIDS patients |
| most common | Viracept (nelfinavir) is the ____ protease inhibitor |
| Prevents | Fusion Inhibitors ____ AIDS virus from entering the immune cells. |
| failed | Fuzeon (enfuvirtide or T-20) is a new class of drugs and is used for patients who have ___ with other therapies. |
| 3 | When combining Retrovirals, the standard is to administer _ or more drugs in combination |
| poor | Patient compliance is extremely ___ due to around the clock dosing and confusing regimens. |
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