MEDCHEM test 1

36 terms by erx

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Enzyme pairing

The Amplichip DNA microarray is used to genotype

CYP2D6/CYP2C19

phenotypes include measuring thermal stability and/or enzyme activity in RBCs for

COMT

enzyme that catalyzes the addition of methyl groups to drugs

COMT/TPMT

TATA box polymorphisms (TA repeats) are common for

UGT1A1

The Invader Molecular Assay is used to detect mutations in

UGT1A1

Codeine-Morphine ratios can fluctuate in patients with polymorphisms in

CYP2D6

Strattera (atomoxetine) pharmacogenetics involve

CYP2D6

Dopamine levels can be altered with polymorphisms in

COMT

Enzyme genotypes of this enzyme include insertions (I) and deletions (D)

ACE

Catalyzes the addition of glucoronic acid to drugs

UGT1A1

Polymorphisms in this enzyme(s) represents a pharmacodynamic issue

ACE/VKORC1

Which is the next enzyme responsible for the majority of Phase I drug metabolisms other than CYP3A4?

CYP2D6

Important enzyme implicated in coagulation cascade

VKORC1

Implicated in detoxifying drugs used to treat Acute Lymphoblastic Leukemia

TPMT

SN-38 metabolism is affected by polymorphisms in

UGT1A1

Enzyme that converts ironotecan to SN-38

Esterase

Enzyme responsible for the largest percent of drug metabolisms

CYP3A4

(S)-Warfarin is metabolized by this polymorphic enzyme

CYP2C9

Enzyme that detoxifies thiopurines through methylation

TPMT

Polymorphisms include insertion and deletion of alleles

ACE

Phase II enzyme that metabolizes SN-38

UGT1A1

Polymorphic enzyme that metabolizes isoniazid, hydrolazine, and procainamide by acetylation

NAT-2

Grapefruit juice inhibits this enzyme

CYP3A4

This enzyme is involved in the initial conversion of the antiplatelet agent prasugel (Effient) to an inactive metabolite

Esterase

Paragon Dx rapid genotyping assay genotypes these two enzymes in order to adjust warfarin dose

CYP2C9/VKORC1

Phenytoin is metabolized by these two enzymes

CYP2C9/CYP2C19

One of the first examples selected by the FDA for inclusion of pharmacogenetic information in drug labeling

TPMT

Metronidazole is an inhibitor of

CYP2C9

Co-administration of codeine (CYP3A4 and CYP2D6) with the CYP3A4 inhibitor clarithromycin can lead to life-threatening respiratory depression in individuals who are

CYP2D6 ultrarapid metabolizers

The variability in warfarin dosing can be explained by polymorphisms in

CYP2C9/VKORC1

Bilirubin's clearance is largely due to

UGT1A1

Omeprazole is metabolized by

CYP2C19

Verigene is a test for genotyping these enzymes

CYP2C9/VKORC1

Infinity is a test for genotyping these enzymes

CYP2C9/VKORC1

eSensor is a test for genotyping these enzymes

CYP2C9/VKORC1

Invader is a test for genotyping

UGT1A1

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