chronic disease characterized by fatigue and weakness rpimarily in muscles innervated by the cranial nerves, as well as in skeletal and respiratory muscles. autoimmune disease
peak age of onset
between 20 and 30 years of age
which sex is more affected?
women are affected three times more often then men
what is patho of MG?
caused by an autoantibody attack on the acetylcholine receptors in the muscle end plate membranes. As a result, nerve impulses are not transmitted to the skeletal muscle at the neuromuscular junction, and muscles cannot contract
causes of MG
not hereditary, small familial incidence, evidence suggests a relationship between MG and hyperplasia (overgrowth) of the thymus gland, strong association between hyperthyroidism and MG
progressive muscle weakness that improves with rest, poor posture, ocular palsies, ptosis, weak or incomplete eye closure, diplopia, respiratory compromise, loss of bowel and bladder control, fatigue, muscle achiness, paresthesias, decreased smell and taste
an exacerbation of myasthenic symptoms caused by not enough anticholinesterase drugs
what causes myasthenic crisis?
usually caused by some type of infection
priority nursing intervention for patient in myasthenia crisis
maintaining adequate respiratory function
acute exacerbation of muscle weakness caused by too many anticholinesterase drugs