Immunology Midterm

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CD40 (2) ligand

CD40L (CD154)

B7 (CD80/86)

CD28

Name 4 receptor/ligand pairs found between a cytotoxic T cell and a target cell.

CD2 -- LFA-3

LFA-1 -- ICAM-1

CD45 -- CD22

TCR/CD8 -- MHC Class I + foreign peptide

Name 2 components of the pre-BCR.

V segment + u constant chain (heavy chain)

sai pseudo-light chain

Name 2 components of the BCR

V segment + u constant chain (heavy chain)

kappa or lambda light chain

What is the pan B cell marker?

CD19

Phagosome

formed from endocytosis of a microbe

CD14 aka

LPS receptor

What amino acid is found in high amounts in defensins?

cysteine

To what region do superantigens bind to?

V beta region of TCR

What enzyme is involved in activation/inhibition of NK cells upon binding to a normal/target cell?

tyrosine kinase

What domain of the MHC class 1 antigen interacts with a CD8+ Tc cell?

alpha-3

Which chromosome encodes MHC in mice?

chromosome 17

What 2 chains make up the peptide binding cleft of MHC 1 and MHC 2 molecules?

MHC 1: alpha-1, alpha-2

MHC 2: alpha-1, beta-1

Name the 3 professional APCs.

dendritic cells

B cells

macrophages

Immunological synapse

interface between APC and T cells

Junctional diversity concludes the process of somatic recombination or V(D)J recombination, during which the different variable gene segments (those segments involved in antigen recognition) of TCRs and immunoglobulins are rearranged and unused segments removed. This introduces double-strand breaks between the required segments. These ends form hairpin loops and must be joined together to form a single strand. This joining is a very inaccurate process which results in the variable addition or subtraction of nucleotides and thus generates junctional diversity.

Which selectin is expressed on endothelium following exposure to IL-1 and TNF?

E-selectin

What is the most efficient antigen presenting cell?

dendritic cell

Name 2 chemotactic molecules for neutrophils.

IL-8 (CXCL8)

C5a

Which Th cells are associated with intracellular infections?

Th1 cells

Which selectin molecule is translocated from the endothelial cell cytoplasm to the cell surface upon exposure to histamine?

P-Selectin

Which blood cells have Fc-epsilon-receptors?

eosinophils

Which selectins are expressed on circulating lymphocytes in non-inflammatory states.

L-selectin

CD21 is aka

CR2

Th3 cells are aka

Tr2 cells

Are neutrophils APCs?

NO!

What region of an Ig determines its idiotype?

variable region

Allotype

small amino acid differences in the Ig constant regions

What chain and region of an Ig determines its isotype?

heavy chain constant region

How many molecules are yielded from papain digestion of Ig?

3

What are the 1st leukocytes to arrive at a site of infection?

neutrophils

Which 2 antibodies can activate the classical pathway of complement?

IgG

IgM

CR2 binds which virus?

Epstein-Barr virus

Name the 3 CDs that make up the B cell co-receptor complex.

CD19

CD21

CD81

During what stage does initial transcription of the kappa or lambda light chain occur?

immature B cell stage

During what stage does somatic recombination of the BCR light chain occur?

pre-B cell stage

What are Bence Jones proteins?

light chain Ig in urine

Which cytokine requires a second signal in order to up regulate iNOS?

TNF

Name 2 sources of hypochlorite in innate immunity.

NADPH oxidase

lysosomal granules

Which Ig can activate the alternative pathway of complement in its aggregated form?

IgA

Which Ig is expressed on immature B cells?

IgM

Which of the following is NOT an anaphylatoxin: C2a, C3a, C4a, C5a

C2a

Name a receptor for C3bi

CR2

During which B cell stage is CD19 first expressed?

pro-B cell stage

During which B cell stage is CD20 first expressed?

pre-B cell stage

Mutation of what protein causes X-linked Agammaglobulinemia (Bruton's)?

Btk kinase

What is combinatorial association?

somatic recombination

Which Ig has 2 subtypes?

IgA

Which Ig is the best agglutinator of RBCs?

IgM

What is the "pan marker" for T cells? Hint: it is the 1st molecule to be expressed.

CD2

Which activated T cell ligand is required for optimal activation of B cells?

CD40L (CD154)

Nam 2 CDs that make up VLA-4.

CD49d

CD29

IL-4 cells (3)

mast cells

Th0

Th2

IL-23 cells (2)

macrophages

dendritic cells

TNF cells (2)

macrophages

Th1

Where is GLYCAM1 found?

HEVs of lymph nodes

GM-CSF cells (2)

macrophages

T cells

IL-15 shares many biological properties with which cytokine?

IL-2

IL-15 cells (3)

nonlymphoid tissues (epithelial, fibroblasts)

monocytes/macrophages

dendritic cells

What 3 cells have CR1?

erythrocytes

B cells

phagocytes

Which complement fragment is a chemoattractant for neutrophils?

C5a

IL-18 cells (2)

monocytes/macrophages

dendritic cells

*non-immune cells as well

What domain found on NALP3 is the recognition portion for various ligands?

leucine-rich domain (LRR)

What 3 cells express CD200?

B cells

T cells

dendritic cells

Name an integrin expressed on monocytes but not on neutrophils.

VLA-4 (CD49d & CD29)

What 2 CDs make up MAC-1?

CD11b

CD18

What 2 types of cells have MAC-1 integrin?

monocytes

neutrophils

Name 3 blood cells that have VLA-4 (CD49d & CD29) integrin.

lymphocytes

monocytes

eosinophils

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