5 Written Questions

1. mass of cells dividing uncontrollably
2. structure carrying genetic material; each species has a characteristic number
   
   humans have 46 (23 pairs)
3. breast cancer susceptibility protein- helps repair DNA at G2 checkpoint (recognizes double-stranded breaks in chromosomes and recruits repair enzymes to fix them); responsible for preventing breast and ovarian cancer
4. protein structure on chromosomes where MTs attach during mitosis
5. division of somatic cells (technically the division of the nucleus; cytokinesis is the division of the cytoplasm and organelles)

5 Matching Questions

1. Diploid
2. Recombinant Chromosomes
3. Cell Cycle Checkpoint
4. Cancer
5. Meiosis produces:

1. a critical point in the cell cycle that is regulated
2. b 2n- cells with paired chromosomes
3. c 4 haploid daughter cells
   not identical to parent cell or each other
4. d out of control cell division
5. e chromosomes produced from the occurrence of crossing over during prophase I in meiosis

5 Multiple Choice Questions

1. -fix problem- move past checkpoint
   -can't fix problem- apoptosis (cell sent down cell suicide pathway)
   -can't fix problem- cell is accidentally allowed to pass through checkpoint
   1. Silencing of Tumor Suppressor Genes
   2. Meiosis produces:
   3. Mitosis produces:
   4. 3 Checkpoint Options is Problem is Detected:
2. egg and sperm combine to produce a diploid zygote
   1. Nondisjunction
   2. Diploid
   3. Fertizlization
   4. Regulators
3. n- cells with unpaired chromosomes (ex: gametes)
   1. Haploid
   2. Allele
   3. Trisomy
   4. Diploid
4. region where sister chromatids attach; site of kinetochore formation
   1. Oncogene
   2. Kinetochore
   3. Cancer
   4. Centromere
5. proto-oncogene/membrane receptor that, when signal is received, genes are turned on that stimulate cell division and inhibits cell from dying; antibodies are used to shut down excess Her2
   1. BRCA2
   2. Tumor
   3. p53
   4. Her2

5 True/False Questions

1. Tumor Suppressor Protein → occurs ONLY in prophase I of MEIOSIS
   exchange of genetic material between NON-sister chromatids

   True        False

2. Oncogene → out of control cell division

   True        False

3. Human Papiloma Virus (HPV) → integrates itself into host genome and its genes, such as the gene for E6, are then transcribed and translated by the host cell

   True        False

4. Functions of Mitosis → mistake during meiosis in which either homologous chromosomes (meiosis I) or sister chromatids (meiosis II) fail to separate

   True        False

5. Silencing of Tumor Suppressor Genes → a normal cell protein that inhibits cell division if conditions are not favorable (if DNA is damaged, may repair it, promote apoptosis of cell, or promote density-dependent inhibition of cell)

   True        False