Organ Systems Exam 5 Pharm

79 terms by tswim 

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Pharmacology relating to Diabetes, Lipidemia, GI, Endocrine

Psyllium

Fiber-like Laxative

Magnesium Hydroxide

Osmotic Lax 1-3hrs

MgSo4

Osmotic Lax 1-3hrs

Sorbital

Osmotic Lax 1-3hrs

Phenolphthalein

Stim Lax 6-8hrs

Bisacodyl

Stim Lax 6-8hrs

Senna

Stim Lax 6-8hrs

Castor Oil

Stim Lax 6-8hrs

Docusate

Stim Lax 1-3hrs

Cisapride

Serotonin 5HT4 Agonist-promote GI motility, decrease acid reflux, diabetic gastroporesis, chronic constipation

Dicyclomine

Anti-diarrheal, Anti-musc,

Diphenoxylate

Anti-diarrheal
Can cross BBB, Opoid agonist

Loperamide

Anti-diarrheal,Toxic megacolon
CANNOT cross BBB, Opoid agonist

Syrup of Ipecac

Anti-emesis
directly affects CTZ (cardiotoxic, myopathy)

Ondansetron

Anti-emesis
serotonin HT3 antagonist (use with glucocorticoids)

Metoclopramide

Anti-emesis, N/V, GERD, diabetic gastroporesis
D2 receptor antatgonist/agonist @ 5HT4 (increase upper GI motility)

Promethazine

Anti-emesis, H1/M receptors

Prochlorperazine

D2/M/H1/5HT
Anti-emesis, antipsychotic

Scopolamine

motion sickness, most efficacious

Diphenhydramine

motion sickness

Dimenhydrinate

motion sickness

Promethazine

motion sickness

Meclizine

motion sickness-less sedative

Budesonide

IBD

Prednisone

IBD

Prednisolone

IBD

5-ASA

IBD, anti-inflammatory
ACTIVE

Sulfasalatine

IBD-Degrades into 5-ASA

Balsalazide

IBD-Degrades into 5-ASA

Mesalamine

IBD-Degrades into 5-ASA

Infliximab

IBD-TNFalpha Ab

Cromolyn Sodium

IBD-prevents act. of mast cells, ulcerative colitis

Prednisone

glucocorticoid for hypoadrenalism, must use with mineralcorticoid

Prednisolone

glucocorticoid for hypoadrenalism, must use with mineralcorticoid

Triamcinolone

glucoc for hypoadrenalism-Asthma

Acetomide

glucoc for hypoadrenalism-Asthma

Betamethasone

glucoc for hypoadrenalism-No salt retention

Dexamethasone

glucoc for hypoadrenalism-No salt retention

Fludocortisone

Most commonly prescribed mineralcorticoid
for hypoadrenalism

Metyrapone

Anti-adrenalcorticoid-inhibits 11-beta-hydrox

Aminoglutethimide

Anti-adrenalcorticoid-inhibits first step

Mifepristone

Anti-adrenalcorticoid-binds to progesterone and glucocorticoid receptors

Spirolactone

Anti-adrenalcorticoid-binds to mineralcorticoids and androgen receptors

Eplerenone

Anti-adrenalcorticoid-aldo antagonist

EDTA

Lead/Mercury antagonist-MUST BE taken with Ca or else heart will stop and hypotenstion

Dimercaporl

Lead/Mercury/Arsenic antagonist-can cause HTN and tachycardia

Succimer

Lead/Mercury/Arsenic antagonist-fewer side effects

Deferoxamine

competes with loosely bound iron

Penicllamine

copper antagonist

sodium nitrate

cyanide poisoning-metheme

sodium thiosulfate

cyanide poisoning-thiocyanate

hydroxycobalamine

cyanide poisoning-b12

Omeprazole

PPI

cimetidine

H2 blocker "take h2 blockers before you Dine think table for 2"

Bismuth, sucralfate

bind to ulcer base, providing physical protection (Peptobismol)

Misoprostol

PGE1 analog
increase mucus, decrease acid

Tetracycline, Metronidazole

Tx of ulcers-H.pylori

Mg(OH)2

Antacid-diarrhea, don't use with Ab, alkalize blood/urine

Al(OH)3

Antacid-diarrhea, don't use with Ab, alkalize blood/urine

Statins

competitive inhibitors of HMG-CoA reductase

fluvastatin

100% absorption (hepatotoxicity, myopathy), don't use with gemfibrozil

rosuvastatin

19hr half life (hepatotoxicity, myopathy), don't use with gemfibrozil

Colestipol

bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial

cholestryamine

bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial

colesevelam

bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial

ezetimibe

an inhibitor of cholesterol absorption by enterocytes in the small intestine

Niacin

oldest antilipemic

fibrates

interact with PPAR, induces perixsomal proliferation

gemfibrozil

fibrates

fenofibrate

fibrates

levothyroxine

t4 precise dosing, hypoallergenic, one daily

liothyronine

t3
more active
cardiotoxic, multiple dosing

liotrix

ratio of t3t4

propylthioruacil

treatment of hyperthyroidism, inhibit thyroid peroxidase, block iodination, block iodotyrosine coupling, block deiodination of t4 to t3, does NOT block release
Liver failure, agranulocytosis

methimazole

treatment of hyperthyroidism, inhibit thyroid peroxidase, block iodination, block iodotyrosine coupling, block deiodination of t4 to t3, does NOT block release

thiocyanate

blocks uptake of iodide

perchlorate

blocks uptake of iodide

iodine

inhibits TH synthesis and release

radioactive iodine

necrosis of follicle cells

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