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5 Written questions

5 Matching questions

  1. pyruvate to acetyl-coa
  2. how krebs differs from glycolysis
  3. step 8
  4. step 3
  5. where does it take place?
  1. a isocitrate (6c) is oxidized to form alpha-ketoglutarate (5c) with the help of isocitrate dehydrogenase, transforming NAD+ into NADH and releasing H+ and CO2
  2. b pyruvate + NAD+ + CoA-SH (coenzyme A) ----pyruvate dehydrogenase complex---> CH3C(=O)SCoA (acetyl coa) + NADH + CO2
  3. c malate (4c) is oxidized into oxaloacetate with the help of malate dehydrogenase, transforming NAD+ into NADH and releasing H+
  4. d no reversal needed, no quick mechanism for NAD+ regeneration (too oxidative), more acetyl-CoA available
  5. e inner mitochondrial matrix

5 Multiple choice questions

  1. citrate (6c) is isomerized to isocitrate (6c) with the help of aconitase
  2. a 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin
  3. oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase
  4. succinyl CoA (4c) is transformed into succinate (4c) with the help of succinyl CoA synthetase, transforming GDP + Pi into GTP with the energy released from the C-S bond
  5. 8 (2 from pyruvate to acetyl coa, 6 from krebs), 2 (glycolysis), 1, 4, 1

5 True/False questions

  1. which intermediates of the krebs cycle can be made into glucose?all of them

          

  2. isocitratethe conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)

          

  3. what is citrate?a secondary alcohol that is oxidized to a ketone (alpha-kg)

          

  4. what do you need to know about CoA?it's normous and requires pantothenic acid, a water soluble vitamin, to make it

          

  5. FADa 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin

          

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