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5 Written questions

5 Matching questions

  1. step 4
  2. step 6
  3. what do you need to know about pyruvate dehydrogenase complex?
  4. step 3
  5. NAD+ vs. NAD: which is the better oxidizing agent? reducing agent?
  1. a its coenzymes include b-vitamins (water soluble) that act as recyclable prosthetic groups; it's the most irreversible reaction in our body/there's no getting around it, so once acetyl-CoA is made, you cannot go back
  2. b alpha-ketoglutarate (5c) is oxidized to form succinyl coA (4c) with the help of alpha-ketoglurate dehydrogenase complex, transforming NAD+ into NADH, bringing in CoA, and releasing CO2 and H+
  3. c isocitrate (6c) is oxidized to form alpha-ketoglutarate (5c) with the help of isocitrate dehydrogenase, transforming NAD+ into NADH and releasing H+ and CO2
  4. d FAD, NAD+
  5. e succinate (4c) is oxidized into fumarate (4c) with the help of succinate dehydrogenase, transforming FAD into FADH2

5 Multiple choice questions

  1. the conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)
  2. inner mitochondrial matrix
  3. it's normous and requires pantothenic acid, a water soluble vitamin, to make it
  4. pyruvate, fats, amino acids, ketone bodies
  5. oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase

5 True/False questions

  1. how krebs differs from glycolysisno reversal needed, no quick mechanism for NAD+ regeneration (too oxidative), more acetyl-CoA available


  2. pyruvate to acetyl-coapyruvate + NAD+ + CoA-SH (coenzyme A) ----pyruvate dehydrogenase complex---> CH3C(=O)SCoA (acetyl coa) + NADH + CO2


  3. FADflavin adenine dinucleotide, a biological oxidizing agent that is reduced to FADH2; comes from riboflavin


  4. NAD+flavin adenine dinucleotide, a biological oxidizing agent that is reduced to FADH2; comes from riboflavin


  5. step 7succinyl CoA (4c) is transformed into succinate (4c) with the help of succinyl CoA synthetase, transforming GDP + Pi into GTP with the energy released from the C-S bond


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