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5 Written Questions

5 Matching Questions

  1. pyruvate to acetyl-coa
  2. step 6
  3. where does it take place?
  4. there are ___ control points
  5. what is citrate?
  1. a the conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)
  2. b pyruvate + NAD+ + CoA-SH (coenzyme A) ----pyruvate dehydrogenase complex---> CH3C(=O)SCoA (acetyl coa) + NADH + CO2
  3. c succinate (4c) is oxidized into fumarate (4c) with the help of succinate dehydrogenase, transforming FAD into FADH2
  4. d 4 (3 within, 1 outside)
  5. e inner mitochondrial matrix

5 Multiple Choice Questions

  1. 8 (2 from pyruvate to acetyl coa, 6 from krebs), 2 (glycolysis), 1, 4, 1
  2. its coenzymes include b-vitamins (water soluble) that act as recyclable prosthetic groups; it's the most irreversible reaction in our body/there's no getting around it, so once acetyl-CoA is made, you cannot go back
  3. isocitrate (6c) is oxidized to form alpha-ketoglutarate (5c) with the help of isocitrate dehydrogenase, transforming NAD+ into NADH and releasing H+ and CO2
  4. fumarate (4c) is transformed into malate (4c) with the help of fumarase, bringing in 1 molecule of H2O
  5. citrate (6c) is isomerized to isocitrate (6c) with the help of aconitase

5 True/False Questions

  1. step 1oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase


  2. what do you need to know about CoA?pyruvate, fats, amino acids, ketone bodies


  3. which intermediates of the krebs cycle can be made into glucose?all of them


  4. NAD+a 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin


  5. step 8malate (4c) is oxidized into oxaloacetate with the help of malate dehydrogenase, transforming NAD+ into NADH and releasing H+


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