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amphetamine purely indirectly acting adrenergic agonist ephedrine indirectly acting alpha and beta adrenergic agonist phenylpropanolamine indirectly and directly acting alpha adrenergic agonist pseudoephedrine indirectly acting agonist and directly alpha adrenergic agonist tyramine displaces CCA and false transmitter; indirectly acting isocarboxazid MAO-A and MAO-B irreversible inhibitor phenelzine MAO-A and MAO-B irreversible inhibitor tranylcypromine MAO-A and MAO-B irreversible inhibitor clorgyline MAO-A irreversible inhibitor moclobemide MAO-A reversible inhibitor selegiline MAO-B irreversible inhibitor rasagiline MAO-B irreversible inhibitor entacapone COMT peripheral inhibitor Cocaine block reuptake of CCAs (CNS) Imipramine prevents CCA reuptake (tricyclic antidepressant) Desipramine prevents CCA reuptake (tricyclic antidepressant) Chlorpromazine prevents CCA reuptake (anti-psychotic) epinephrine alpha 1 and 2, beta 1 and 2 agonist norepinephrine alpha 1 and 2, beta 1 and 2 agonist dopamine low dose: D1 and D2 agonist high dose: alpha 1 and 2, beta 1 agonist methoxamine alpha 1 agonist phenylephrine alpha 1 agonist clonidine alpha 2 agonist guanfacine alpha 2 agonist guanabenz alpha 2 agonist Apraclonidine alpha 2 agonist (OAG) alpha- methylnorepinephrine alpha 2 agonist dobutamine low dose: beta 1 agonist high dose: beta 2 agonist, alpha 1 agonist carteolol partial alpha agonist (beta 1 = beta 2) ISA acebutolol partial agonist (beta 1 < beta 2) penbutolol partial alpha agonist (beta 1= beta 2) ISA pindolol partial alpha agonist (beta 1= beta 2) ISA albuterol beta 2 agonist (bronchodilator) metaproterenol beta 2 agonist (bronchodilator) terbutaline beta 2 agonist (bronchodilator, uterus) ritodrine beta 2 agonist (uterine relaxant) bitolterol beta 2 agonist (bronchodilator) pirbuterol beta 2 agonist (bronchodilator) solabegron beta 3 agonist YM178 beta 3 agonist (bladder) methylphenidate indirectly acting adrenoceptor agonist (mild CNS) metaraminol directly alpha receptor agonist and indirectly acting adrenoceptor agonist ibopamine D2 >D1>B2>B1= A1 = A2 (N/V via D2) dopexamine D2, beta 2 agonist, D1 fenoldopam D1 agonist (renal failure) bromocryptine D2 agonist, D1 partial agonist pergolide D2 agonist, D1 antagonist cabergoline D2 agonist ropinirole D2 and D3 agonist (Parkinson's) pramipexole D2 and D3 agonist (Parkinson's) phentolamine alpha antagonist (H1, muscarinic antagonist) tolazoline alpha antagonist (H1, muscarinic antagonist) phenoxybenzamine alpha antagonist (H1, muscarinic, 5HT antagonist) irreversible prazosin alpha 1 antagonist (CNS decreases symp) alfuzosin alpha 1 antagonist (bladder) doxazosin alpha 1 antagonist tamsulosin alpha 1(a) antagonist (bladder, abnormal ejaculation) terazosin alpha 1 antagonist silodosin alpha 1a antagonist (bladder, abnormal ejaculation) carvedilol alpha 1 antagonist, beta nonselective antagonist labetalol alpha 1 antagonist, beta nonselective antagonist yohimbine alpha 2 antagonist (erection) atipamezole alpha 2 antagonist propranalol beta nonselective antagonist nadolol beta nonselective antagonist timolol beta nonselective antagonist metoprolol beta 1 antagonist atenolol beta 1 antagonist acebutolol beta 1 antagonist nebivolol beta 1 antagonist and NO stimulatant esmolol beta 1 antagonist (short duration of action) acetylcholine nicotinic and muscarinic agonist (act on M2 receptors to reduce NT) atropine muscarinic antagonist botulinum toxin A indirect antagonist (binds to synaptobrevin) w-conotoxin indirect nicotinic antagonist (blocks Ca channels) hexamethonium nicotinic antagonist a-latrotoxin causes all vesicles to fuse to membrane = massive release of Ach (black widow) muscarine muscarinic agonist (no ChE met) neostigmine cholinesterase inhibitor Nicotine Nn nicotinic agonist opiates act on w-receptors to reduce Ach release Norepinephrine (cholinergic) act on a2 receptors to reduce Ach and NE release Tetrodotoxin blocks Na channels preventing AP Tubocurarine Nm nicotinic antagonist, competative Donepezil ChE inhibitor (reversible, CNS, alzheimers) Galantamine ChE inhibitor (reversible, CNS, alzheimers) Rivastigmine ChE inhibitor (reversible, CNS, alzheimers) Tacrine ChE inhibitor (reversible, CNS, alzheimers) Pyridostigmine ChE inhibitor (reversible, NMJ) Edrophonium ChE inhibitor(reversible, short acting, NMJ) Ambedonium ChE inhibitor (reversible, NMJ) Demecarium ChE inhibitor(reversible, long acting, NMJ) Neostigmine ChE inhibitor, cholinergic agonist (reversible) Physostigmine ChE inhibitor (reversible, CNS) Diisopropyl phosphofluoridate (DFP) ChE inhibitor (irreversible, CNS) Echothiophate ChE inhibitor (irreversible, low toxicity) Malathion ChE inhibitor (irreversible, CNS, insects) Parathion ChE inhibitor (irreversible, CNS, insects) Obidoxime ChE reactivator Pralidoxime ChE reactivator Methacholine cholinomimetic M and little N (ChE met) Aceclidine cholinomimetic M and N (not broken down by ChE) Carbachol cholinomimetic M and N (not broken down by ChE) Bethanechol cholinomimetic M (not broken down by ChE) Cevimeline cholinomimetic M (not broken down by ChE) Pilocarpine cholinomimetic M (not broken down by ChE,sweat glands and eyes) Atropine M antagonist, no CNS Scopolamine M antagonist, CNS Benztropine M antagonist, Parkinson Ipratropium M antagonist, no mucocilliary Tiotropium M1/M3 long duration homatropine M antagonist, short duration, cycloplegia, eye cyclopentolate M antagonist, short duration, cycloplegia, eye tropicaminde M antagonist, short duration, cycloplegia, eye dicyclomine M antagonist, antispasmodic oxyphencyclimine M antagonist, antisposmodic darifenacin M3 antagonist, urological solifenacin M antagonist, urological, very specific Trospium M antagonist, urological, very specific Oxybutynin M antagonist, urological, SE dry mouth tolterodine M antagonist, urological specific ___ zepine M1 antagonist, ulcer hexamethonium Nn antagonist Mecamylamine Nn antagonist Trimethaphan Nn antagonist, rapid onset and short half life Atracuriaum Nm blocking, competitive, ChE met Cistracurium Nm blocking, competitive Mivacurium Nm blocking, competitive, bChE, short duration Doxacurium Nm blocking, competitive, long duration Pipercuronium Nm blocking, competitive, long duration Pancuronium Nm blocking, competitive, sugammadex Vecuronium Nm blocking, competative, long duration, sugamedex Rocuronium Nm blocking, competitive, long duration, strong sugammadex Succinylcholine Nm blocking, depolarizing Dantrolene treats malignant hyperthermia