Antibacterial - Inhibit Cell Wall Synthesis
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Created by:
pichaya_cha on April 5, 2011
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6 terms
Terms | Definitions |
|---|---|
 Beta-Lactam Antibiotics | Prevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands. Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin |
| Vancomyocin | Inhibits linkages of peptidoglycan constituents. Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall) Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix |
| Cycloserine | Competitively inhibits D-alanine ligase enzyme so cannot syntheses from L to D-alanine Don't have crosslinking if not have D-alanine at the end |
| Bacitracin | Interferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks |
| Penicillin | Ampicillin and Amoxicillin o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase o Effective aginst gram (-) Extended-spectrum penicillin's *not know o Works against most bacteria, gram(-) and gram (+) Carbenicillin, Ticaracillin, Azlocillin, Piperacillin. - May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases - Can cause antiplatelet effects |
| Cephalosporins | Come from the fungus CephalosporiumAcremonium. Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-) Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases |
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