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2 Written Questions

2 Multiple Choice Questions

  1. Inhibits linkages of peptidoglycan constituents.

    Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)

    Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

    Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix
  2. Come from the fungus CephalosporiumAcremonium.

    Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-)

    Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases

2 True/False Questions

  1. PenicillinAmpicillin and Amoxicillin
    o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
    o Effective aginst gram (-)

    Extended-spectrum penicillin's *not know
    o Works against most bacteria, gram(-) and gram (+)

    Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
    - May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
    - Can cause antiplatelet effects

          

  2. Beta-Lactam AntibioticsPrevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.

    Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin

          

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