2 Written questions
2 Multiple choice questions
- Ampicillin and Amoxicillin
o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
o Effective aginst gram (-)
Extended-spectrum penicillin's *not know
o Works against most bacteria, gram(-) and gram (+)
Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
- May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
- Can cause antiplatelet effects
- Interferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks
2 True/False questions
Cephalosporins → Come from the fungus CephalosporiumAcremonium.
Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-)
Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases
Vancomyocin → Inhibits linkages of peptidoglycan constituents.
Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)
Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides
Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix