2 Written Questions
2 Multiple Choice Questions
- Inhibits linkages of peptidoglycan constituents.
Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)
Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides
Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix
- Come from the fungus CephalosporiumAcremonium.
Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-)
Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases
2 True/False Questions
Penicillin → Ampicillin and Amoxicillin
o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
o Effective aginst gram (-)
Extended-spectrum penicillin's *not know
o Works against most bacteria, gram(-) and gram (+)
Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
- May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
- Can cause antiplatelet effects
Beta-Lactam Antibiotics → Prevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.
Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin