| Term | Definition |
|---|
| Nociceptive pain | Traumatic, Inflammatory, Colicky, Vascular |
| Neuropathic pain | Deafferentiation, Sympathetically mediated |
| Neuropathic Pain | Any pain syndrome where the predominant mechanism is a aberrant somatosensory processing in the CNS or PNS |
| Common neuropathic pain etiologies | MS, VZV, Sciatica, AIDS, Diabetic neuropathy, Amputation, Spinal surgery, etc. |
| Deaffarentiation Pain | Type of neuropathic pain; Stems from loss or interruption of afferent signals |
| Sympathetically mediated neuropathic pain | Neuropathic pain that caused through pathology of the EFFERENT mediated limb of pain reflexes |
| Examples of DA Neuropathic Pain | Phantom Limb Syndrome, Post-herpetic neuralgia, Central pain after CNS injury |
| Examples of Sympathetic Neuropathic Pain | Chronic pain syndrome, soft tissue damage/nerve damage; Associated with autonomic changes like sweating; Trophic changes seen as well - atrophy, hair loss, etc. |
| HIV and Neuropathic pain | Neuropathic pain occurs from HIV/AIDS as well as prolonged or combo use of treatment, such as NRTIs |
| Peripheral neuropathy induced by Antiretrovirals | Onset weeks to months after initiation; Typically bilateral, symmetric paresthesia of toes and feet that may progress upwards with accompanying pain |
| NRTIs associated with neuropathy | Didanosine, Stavudine, Zalcitabine (ddI, d4T, ddC) |
| Trigeminal neuralgia | intense paroxysmal neuralgia along the trigeminal nerve |
| Carbamazepine | Can be helpful (>50% response rate) in peripheral neuralgia, like CNV involvement |
| Gabapentin | May prove effective in neuropathic pain after all other treatments fail; May affected voltage gated Sodium channels. |
| Amitryptiline in Neuropathic Pain | Inhibits reuptake of Serotonin or Noradrenaline; Allow greater descending pain control at enkephalinergic receptor; Lowers pain |
Combine with other sets
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