pharm test 2 A matching w/o H
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21 terms
Terms | Definitions |
|---|---|
 ```Common side effects of class 1b | no prolonged QT, mostly CNS effects (drowsiness, agitation, muscle twitch, seizures, paresthesias) |
| ```Common side effects of class 1c | prolonged QT, TdP not for use in HF |
| ```Common SE of Dofentilide | Ventricular arrhythmias, TdP, avoid other agents known to prolong QT interval. Drugs that inhibit metabolism in liver: dilt, verapamil, amio, sotalol, TCA, phenothiazines and diuretics. |
| ```Quinidine metabolism? | Liver 80%, Kidney 20% |
| ```Disopyrimide metabolism? | Liver 30%, Kidney 70% |
| ```Tocainide metab? | Liver 60-65% |
| ```Flecainide metab? | Liver 75%, Kidney 25% |
| ```What are the indications of quinidine? | Effective in the tx of chronic and supraventricular arrhythmias. Often given to slow atrial rate in the presence of atrial fibrillation. |
| ```What are the major S.E. of procainamide? | hypotension with rapid IV admin agranulocytosis, SLE, prolong QT, may cause agranulocytosis. |
| ```What are the major drug interactions associated with procainamide? | Increased effect of skeletal muscle relaxants, lidocaine, and neuromuscular blockers (succinylcholine), increased plasma/Napa levels with cimetidine, rantidine, BBs, and amiodarone, increased NAPA levels with trimethoprim. |
| ```Explain the indications for disopyramide. | Suppresses atrial and ventricular arrhythmias. |
| ```What are the major precautions for disopyramide? | has significant negative inotropic effects which can worsen CHF, anticholinergic SEs, |
| ```What are the major precautions for propafenone? | Should be avoided in patients with CAD, bronchospastic disorders, uncontrolled CHF, or conduction disorders (AV block or SSS), and bradycardia. |
| ```What are the major precautions of sotalol? | not for patients with HF or heart block, renal dysfunction, may cause TdP |
| ```What are the major precautions for ibutilide? | stop drugs which may prolong the QT interval at least 5 half lives before starting hold at least 4 hours after. |
| ```dofetilide metab? | primarily excreted in urine, only partially in the liver |
| ***MOA of K sparing diuretics | - direct action on renal tubular x-port mechanism on distal convoluted tubule - increased excretion of Na+, Cl, HCO3, urinary pH - N increase in K excretion |
| ```where do thiazide diuretics work? | 1st in cortical portions of the loop, ascending portion of the loop of Henle, proximal and distal renal tubules. Increases urinary excretion of Na, Cl-, HCO3-. |
| ```where do loop diuretics work? | inhibit reabsorption Na+, Cl- primarily in the medullary portions of ascending limbs of the loop of Henle |
| ```common SE of quinidine | diarrhea, conchonism, very increased dig, TdP, atrial/ventricular arrythmias |
| ```dofentilide metab? | primarily excreted in urine |
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