what causes altered absorption?
Increased transit time through GI tract
Decreased absorption of medications requiring active transport
what are drugs requiring active transport
calcium, iron, vitamin B12
what causes changes in distribution?
decreased total body water
increased body fat
what is of note in malnourished elderly?
may have decreased albumin resulting in increased concentrations of highly protein-bound drugs
what is a drug with a narrow therapeutic index?
what is altered in liver metabolism?
phase 1 reactions:
what is altered in excretion?
what is the main drug requiring renal elimination?
what creatinine clearance requires dose adjustment?
what does coumadin interact with in seniors?
what do ace inhibitors interact with in seniors?