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pathogen

infectious agents that cause disease; mostly viruses, bacteria, protists, and fungi

immune system

system which enables an animal to avoid or limit many infections

innate immunity

active immediately upon infection and are same whether or not pathogen has been encountered previously; includes barrier defenses as well as defenses that combat pathogens after they enter the body

acquired immunity

aka adaptive immunity; activated after innate immune defenses take effect and develop more slowly; enhanced by previous exposure to the infecting pathogen; found only in vertebrates

lysozyme

enzyme that digests microbial cell walls

hemocyte

immune cells which circulate within hemolymph; some carry out phagocytosis; others trigger production of chemicals that kill microbes and help entrap multicellular parasites

hemolymph

insect equivalent of blood

phagocytosis

ingestion and digestion of bacteria and other foreign substances

antimicrobial peptides

secretion triggered by encounters with pathogens in hemolymph; circulate throughout body of insect and inactivate or kill fungi and bacteria by disrupting plasma membranes

events in phagocytic cell

1. pseudopodia surround microbes
2. microbes engulfed into cell
3. vacuole containing microbes forms
4. vacuole and lysosome fuse
5. toxic compounds and lysosomal enzymes destroy microbes
6. microbial debris released by exocytosis

barrier defenses

outer covering (such as skin or shell) which provides significant obstacle to invasion by microbes that are present on the body

barrier defenses in mammals

epithelial tissues block entry of many pathogens; include skin, mucous membranes, and secretions

mucus

viscous fluid that enhances defenses by trapping microbes and other particles

body secretions

create environment hostile to many microbes; lysozyme in saliva, mucous secretions, and tears; acidic environment of the stomach; acidic secretions from sebaceous (oil) and sweat glands

leukocytes

phagocytic white blood cells

protein Toll

receptor on surface of immune response cells in insects

Toll-like receptor (TLR)

receptors in vertebrates that recognize fragments of molecules characteristic of a set of pathogens; recognized marcomolecule normally absent from vertebrate body and is an essential component of a class of microbes

neutrophil

most abundant phagocytic cells in mammalian body; signals from infected tissues attract neutrophils which then engulf and destroy microbes

macrophages

"big eaters" provide more effective phagocyctic defense; some migrate throughout body; others reside permanently in various organs and tissues; those in spleen, lymph nodes, and other tissues of lymphatic system are particularly well positioned to combat pathogens; key role in initiating secondary immune response by presenting antigens to memory helper T cells

lymphatic system

consists of lymphatic vessels through which lymph travels and various structures that trap foreign molecules and particles

flow of lymph

1. interstitial fluid bathing tissues, along with white blood cells in it, continually enters lymphatic vessels
2. fluid inside lymphatic system, known as lymph, flows through lymphatic vessels throughout body
3. within lymph nodes, microbes and foreign particles present in circulating lymph encounters macrophages and other cells that carry out defensive actions
4. lymphatic vessels return lymph to the blood via two large ducts that drain into veins near the shoulders

eosinophils

low phagocytic activity but are important in defending against multicellular invaders such as parasitic worms; position themselves against parasite's body and discharge destructive enzymes that damage invader

dendritic cells

populate tissues that are in contact with the environment; stimulate development of acquired immunity against microbes they encounter; important in triggering primary immune response (serve as sentinels in epidermis and other tissues frequently exposed to foreign antigens; migrate from infection site to lymphoid tissues)

interferon

proteins that provide innate defense against viral infections; virus-infected body cells secret interferons, inducing nearby cells to produce substances that inhibit viral reproduction; limit cell-to-cell spread of viruses in the body; white blood cells may secret different type of interferon that helps activate macrophages

complement system

consists of roughly 30 proteins in blood plasma that function together to fight infections; proteins circulate in inactive state and are activated by substances on the surface of many microbes; activation results in cascade of biochemical reactions leading to lysis of invading cells; also functions in inflammation and acquired defenses

inflammatory response

changes brought about by signaling molecules released upon injury or infection; pain and swelling!

histamine

important inflammatory signaling molecule; stored in mast cells

mast cells

connective tissue cells that store chemicals in granules for secretion

progression of events in local inflammation

1. activated macrophages and mast cells at injury site release signaling molecules that act on nearby capillaries
2. capillaries widen and become more permeable, allowing fluid containing antimicrobial peptides to enter tissue; signaling molecules released by immune cells attract additional phagocytic cells
3. phagocytic cells digest pathogens and cell debris at the site and tissue heals

pus

fluid rich in white blood cells, dead microbes, and cell debris

systemic

throughout the body

fever

systemic inflammatory response; some toxins produced by pathogens, as well as substances called pyrogens released by activated macrophages, can reset body's thermostat to higher temperature

pyrogens

substance released by activated macrophages that reset body's thermostat to higher temperature

septic shock

overwhelming systemic inflammatory response; often life-threatening; characterized by very high fever, low blood flow, and low blood pressure

natural killer cells (NK cells)

help recognize and eliminate certain diseased cells in vertebrates; attach to stricken cells without class I MHC molecule and release chemicals that lead to cell death, inhibiting further spread of virus or cancer

lymphocytes

white blood cells critical for acquired immune defense; B cells and T cells are types of lymphocytes; originate from stem cells in bone marrow

T cells

lymphocytes that migrate from bone marrow to thymus and mature there; recognize and inactive foreign cells and molecules

thymus

organ in thoracic cavity above the heart

B cells

lymphocytes that mature in the bone marrow; recognize and inactive foreign cells and molecules; present antigens to helper T cells

immunological memory

enhanced response to a foreign molecule encountered previously

cytokines

proteins that help recruit and activate lymphocytes; secreted by macrophages and dendritic cells

antigen

any foreign molecule that is specifically recognized by lymphocytes and elicits a response from them; mostly proteins or polysaccharides; some released into extracellular fluid while others protrude from surface of pathogens or other foreign cells

antigen receptor

antigen-specific receptors on B and T cells that recognize antigens; bind to antigens via noncovalent bonds that stabilize interaction between epitope and binding surface

plasma cells

given rise by B cells; secrete soluble form of antigen receptor

antibody

secreted protein that is a soluble form of antigen receptor; also known as immunoglobulin (Ig)

epitope

antigenic determinant; small accessible portion of an antigen; single antigen generally has several different epitopes, each capable of inducing response from lymphocyte

specificity

lymphocyte recognize same epitope

B cell receptor

Y shaped molecule consisting of four polypeptide chains: two identical heavy chains and two identical light chains with disulfide bridges linking chains together; transmembrane region near one end of each heavy chain anchors receptor in cell's plasma membrane; short tail region at end of heavy chain extends into cytoplasm; recognize and bind to antigen regardless of whether antigen is free or on surface of pathogen

constant region (C region)

region in both light and heavy chains where amino acid sequences vary little among receptors present on different B cells; includes cytoplasmic tail and transmembrane region of heavy chain and all of disulfide bridges

variable region (V region)

within two tips of Y shape of both light and heavy chains; amino acid sequence varies extensively from one B cell to another; asymmetrical binding site for antigen

T cell receptor

two different polypeptide chains (alpha and Beta chain) linked by a disulfide bridge; transmembrane region, variable regions, constant regions; bind only to antigen fragements that are displayed or presented on surface of host cells

major histocompatability complex (MHC)

group of genes that produce a host cell protein that can present an antigen fragment to T cell receptors

antigen fragment

peptide antigens; smaller pieces of pathogen proteins that result when a pathogen is inside host cell and enzymes in cell cleave proteins; bind to MHC molecule inside cell

antigen presentation

display of an antigen fragment on the cell surface; movement of MHC molecule and bound fragment to cell surface

class I MHC molecules

found on almost all cells of body (excepted non-nucleated cells such as red blood cells); bind to peptide fragments of foreign antigens synthesized within cell; recognized by cytotoxic T cells

cytotoxic T cells

special group of T cells that recognize class I MHC molecules displaying bound antigen fragments

class II MHC molecules

made by few cell types, mainly dendritic cells, macrophages, and B cells; typically bind to antigen fragments derived from foreign materials that have been internalized through phagocytosis or endocytosis

antigen-presenting cells

dendritic cells, macrophages, and B cells; key role in displaying internalized antigens; display antigens for recognition by cytotoxic T cells and helper T cells

helper T cells

group of T cells that assist both B cells and cytotoxic T cells

3 major properties of acquired immune system

1. tremendous diversity of receptors ensures even pathogens never before encountered will be recognized as foreign
2. ability to recognize vast numbers of foreign molecules coexist with lack of reactivity against molecules that make up organism's own cells and tissues
3. response to an antigen that has been previously encountered is stronger and more rapid than initial response

immunoglobulin gene rearrangement

1. recombination deletes DNA between randomly selected V and J segments
2. transcription of permanently rearranged functional gene
3. RNA processing
4. Translation

effector cells

short-lived lymphocytes that attack antigen and any pathogens producing that antigen

memory cells

long-lived and less numerous; bear receptors specific for the antigen

clonal selection

proliferation of lymphocyte into clone of cells in response to binding an antigen

primary immune response

production of effector cells from a clone of lymphocytes during first exposure to an antigen

secondary immune response

secondary exposure to same antigen; response is faster, of greater magnitude, and more prolonged

humoral immune response

involves activation and clonal selection of effector B cells, which secrete antibodies that circulate in the blood and lymph

cell-meditated immune response

activation and clonal selection of cytotoxic T cells, which identify and destroy target cells

CD4

protein found on surface of most helper T cells that bind to class II MHC molecules; helps keep helper T cell and antigen-presenting cell joined

CD8

protein found on most cytotoxic T cells; enhances interaction between target cell and cytotoxic T cell; binding of CD8 to class I MHC molecule helps keep two cells in contact while cytotoxic T cell is activated

killing action of cytotoxic T cells

1. activated cytotoxic T cell binds to class I MHC-antigen fragment complex on targeted cell via its TCR and aid of CD8
2. T cell releases perforin molecules which form pores in target cell membrane, and granzymes, enzymes that break down proteins (enter cell by endocytosis
3. granzymes initiate apoptosis within target cell, leading to fragmentation of nucleus and cytoplasm and eventually cell death

B cell activation

1. after antigen-presenting cell enguls and degrade bacterium, displays an antigen fragment complex with class II molecule; helper T cell recognizes complex is activated with aid of cytokines secreted from antigen-presenting cell, forming clone of activated helper T cells
2. B cell with receptors for same peptide internalizes antigen and displays it on cell surface in complex with class II MHC protein; activated helper T cell bearing receptor specific for displayed antigen fragment binds to B cell
3. activated B cell proliferates and differentiates into antibody-secreting plasma cells and memory B cells; secreted antibodies are specific for the same bacterial antigen that initiated response

polyclonal

antibody tools that are the products of many different clones of B cells, each specific for a different epitope

monoclonal

antibody tools prepared from a single clone of B cells grown in culture

monoclonal antibodies

identical and specific for same epitope on an antigen; particularly useful for specific molecules

neutralization

antibodies bind to surface proteins of virus or bacterium, thereby blocking pathogen's ability to infect host cell; sometimes bind to and neutralize toxins released in body fluids

opsonization

antibodies bound to antigens present readily recognized structure for macrophages and thereby increase phagocytosis

activation of complement system and pore formation

binding of antibodies to antigens on surface of foreign cell activates complement system; membrane attack complex then forms pores in foreign cell's membrane, allowing water and ions to rush in, lysing the cell

membrane attack complex

complex that forms a pore in membrane of foreign cell

active immunity

immunity in response to infection; clones of memory cells form

passive immunity

transferred antibodies from pregnant woman to her fetus; through IgG antibodies that cross the placenta

IgA antibodies

passed from mother to infant in breast milk; provide additional protection against infections which infant's immune system develops

immunization

vaccination; induced active immunity; many use antigens to make vaccines

artificial passive immunization

antibodies from immune animal injected into nonimmune animal

immune rejection

cells from another person recognized and attacked by immune defenses

allergen

antigens that cause exaggerated or hypersensitive responses

IgE antibodies

involved in most common allergies

degranulation

release of histamine by mast cells and other inflammatory agents from granules

anaphylactic shock

whole-body, life-threatening reaction that can occur within seconds of exposure to an allergen; develops when widespread mast cell degranulation triggers abrupt dilation of peripheral blood vessels, causing precipitous drop in blood pressure

autoimmune disease

immune system turns against particular molecules of the body

systemic lupus erythematosus

immune system generates antibodies against histones and DNA released by normal breakdown of body cells

rheumatoid arthritis

damage and painful inflammation of cartilage and bone of joints

Type 1 diabetes mellitus

insulin-producing beta cells of pancreas are targets of autoimmune cytotoxic T cells

multiple sclerosis

T cells infiltrate central nervous system, leading to destruction of myelin sheath that surrounds many neurons

immunodeficiency

disorder in which ability of an immune system to protect against pathogens is defective or absent

inborn immunodeficiency

genetic or developmental defect in immune system (such as antibodies or proteins of complement system)

severe combined immunodeficiency (SCID)

functional lymphocytes are rare or absent

acquired immunodeficiency syndrome (AIDS)

caused by virus

antigenic variation

changes in epitope expression; regular events for some viruses and parasites

latency

viruses remain in host without activating immune defenses, ceasing production of viral products targeted by lymphocytes

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