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staph skin diseases
VIRULENCE FACTORS

coagulase
proteases, lipases, hyaluronidase
penicillinase
exfoliative toxin
staphylokinase

staph virulence factor
COAGULASE

impedes progress of leukocytosis into infected areas by produceing clots

staph virulence factor
PROTEASES, LIPASES, HYALURONIDASE

degrade surrounding tissues so the infection can spread

staph virulence factor
PENICILLINASE

degrade penicillin

staph virulence factor
EXFOLIATIVE TOXIN

causes seperation of the dermis and epidermis

staph virulence factor
STAPHYLOKINASE

digests blood clots

FOLLICULITIS

disease caused by staph aureus
inflammation of the hair follicle

HIDRADENITIS

dz caused by staph aureus
inflammation of a gland

FURNUCLES (BOILS)

dz caused by staph aureus
when the infection extends from the follicle or gland into surrounding tissues

CARBUNCLES

dz caused by staph aureus
larger, deeper leisions resulting from inter connection of multiple furnucles

IMPETIGO

dz caused by staph aureus
superficial skin infection that causes the skin to flake or peel off

CELLULITIS

dz caused by staph aureus
caused by fast-spreading infection in the dermis and subcutaneous tissues

SCALDED SKIN SYNDROME (SSS)

dz caused by staph aureus
system infection mediated by phage-encoded exfoliative toxins in the blood stream

NECROTIZING FASCIITIS "FLESH-EATING" DISEASE

dz caused by staph aureus
enzymes adn toxins destroy tissue causing movement of the bacteria into deeper tissues

STREP SKIN DISEASE
VIRULENCE FACTORS

streptokinase
hyaluronidase
M protein
Streptolysins SLO and SLS

strep virulence factor
STREPTOKINASE

cleaves plasminogen to degrade tissues

strep virulence factor
HYALURONIDASE

digests hyaluronic acid

strep virulence factor
M PROTEIN

inhibits phagocytosis

strep virulence factor
STREPTOLYSINS SLO AND SLS

hemasins

IMPETIGO

dz caused by strep pyogenes

CELLULITIS

dz caused by strep pyogenes

NECROTIZING FASCIITIS

dz caused by strep pyogenes

ERYSIPELAS

dz caused by strep pyogenes

GAS GANGRENE

-caused by Clostridium perfingens
-gases produced from fermentation of amino acids and glycogen in the dead tissues
-tx debridement, sx, hyperbaric oxygen therapy, amputation

CHICKEN POX

-vesicular rash dz
-caused by varicella zoster virus
-shingles- can occur years after exposure and is caused by latent virus in CNS
-attenuated vaccine is available

CONGENITAL VARICELLA SYNDROME

when mothers contract varicella zoster virus early in pregnancy

SMALL POX

-vesicular rash dz
-caused by variola virus
-prevented with vaccinia vaccine (cow pox)

MEASLES (rubeola)

-maculopapular rash dz
-caused by measles virus
-characterized by appearance of sm. oral leisions known as Kopliks spots
-prevented with attenuated MMR vaccine
--complication of =
Subacute sclerosing panencephalitis (SSPE)- slow progressive brain degeneration 2-10yrs after infection

RUBELLA (german measles)

-maculopapular rash dz
-caused by rubella virus
-2 forms
*postnatal- acquired after birth
*congenital rubella syndrome- virus obtained in utero
-prevented with attenuated MMR vaccine

ERYTHEMA INFECTIOSUM (fifth disease)

-maculopapular rash dz
-caused by parvo virus B19
-rash resembles slapped cheek and then spreads to other parts of the body

EXANTHEM SUBITUM (roseola)

-maculopapular rash dz
-caused by human herpes virus type 6 (HHV-6)
-begins abruptly with high fever that may cause convulsions

WARTS (papillomas)

-wartlike eruptions
-caused by human papilloma virus (HPV)
-benign, squamous epithelial growth on skin or mucous membranes
EXAMPLES
-common warts
-plantar warts
-flat warts

MOLLUSCUM CONTAGIOSUM

-wartlike eruptions
-caused by a pox virus
-leisions are smooth, waxy nodules containing a milky virus filled fluid

LEISHMANIASIS

-large pustular skin leison
-caused by the protozoan Leishmania
-zoonotic dz tranmitted by sand flies
3 TYPES:
-cutaneous leishmaniasis
-mucocutaneous leishmaniasis
-systemic leishmaniasis

DERMATOPHYTES

most common cause of fungal skin infections
--causative agents include: trichophyton, microsporum, epidermonphyton

TINEA CAPITUS

fungal infection of scalp

TINEA CORPIS

fungal infection of body

TINEA BARBAE

fungal infection beard

TINEA MANUUM

fungal infection of hand

TINEA CHURIS

fungal infection of groin aka jock itch

TINEA AXILLARIS

fungal infection of arm pit

TINEA PEDIS

fungal infection of feet aka atheletes foot

TINEA LINGUIUM

fungal infection of nares

TINEA VERSICOLOR

fungal infectoin with patchy scaling

BACTERIAL CONJUNCTIVITIS

commonly cause by staph epi, strep sp, haemopilus, influenzae, moraxella sp.

NEONATAL EYE INFECTIONS

commonly caused by Neisseria gonorrhea and Clamydia trachomatis

VIRAL CONJUNCTIVITIS

commonly caused by adenovirus

TRACHOMA

chronic infection of the epithelial cells of the eye caused by Clamydia trachomatis
-pannus- infiltration of leukocytes causes a pseudomembrane of inflammatory cells to form over the cornea

KERATITIS

invation of deep eye tissues that can lead to complete corneal destruction
-common cause is herpes simplex virus

RIVER BLINDNESS

chronic heliminth infection caused by onchecerca velvulus carrying bacteria Wolbachia
-transmitted by biting black flies

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