Bone Mineral Homeostasis Pharmacology
About this set
Created by:
KariYoung on April 20, 2011
Subjects:
pharmacology, bone, osteoporosis
Log in to favorite or report as inappropriate.
Order by
34 terms
Terms | Definitions |
|---|---|
 What advantage does calcitriol have over other vitamin D preparations? | kidney conversion to active form not necessary (already is 1,25(OH)2vitD3 form) |
| How does vit D regulate bone mineralization? | RANKL induction, osteocalcin |
| What does vit D do in the intestine? | induce prot synth (ca binding), modulate ca flux over brush border and basolat |
| For what conditions is vit D used? | osteoporosis, osteomalacia/rickets, hypoPTH, chronic renal failure |
| What is teriparatide? | PTH preparation |
| What does teriparatide do (to calcium and phosphate levels)? | increase Ca, decrease PO4 |
| How does teriparatide exert effects in bone? How does administration affect the result? | increase RANKL, induce osteoclasts (help - MCSF, inhibited by OPG) Continuous - bone resorption, pulsatile - bone formation |
| What does teriparatide do to ion transfer in the kidney? vit D synth? | increase Ca, Mg reab, otherwise increase excretion, increase vit D synth |
| What is teriparatide used to treat? | osteoporosis (first line) |
| What are first line osteoporosis drugs? | teriparatide, bisphosphonates |
| What does fibroblast growth factor 23 do? | (product of osteoblasts/osteoclasts) inhibits vit D and po4 reabsorp |
| What does calcitonin treat? | hypercalcemia, paget's, osteoporosis (2nd line) |
| What does calcitonin do to calcium and phosphate levels? | decrease both |
| What does calcitonin do in bone? | direct inhibition of osteoclasts |
| What does calcitonin do in the kidney? | decrease reabsorption of Ca and PO4 |
| What do glucocorticoids do to bone homeostasis? | decrease formation, increase Ca excretion, block vit D dep Ca transport in intestine |
| What are glucocorticoids used to treat (in relation to calcium/bone)? | hypercalcemia of high vit D malignancy, vit D tox |
| What do estrogens do in bone homeostasis? | decrease bone-resorbing PTH action (decrease accelerated bone loss post-menopause, side effects therefore 2nd line), increase vit D |
| What do bisphosphonates do? 1st gen specific? amino specific? | inhibit bone dissolution by direct hydroxyapatite crystal binding, (1st gen) ATP analog accum leads to osteoclast apoptosis, (amino) inhibit mevalonate path with enzyme block (critical to osteoclasts) |
| Which drugs must be taken on an empty stomach? | bisphosphonates |
| Which drugs cause esophagitis/erosion? | bisphosphonates |
| Which drugs cause rare jaw osteonecrosis? | bisphosphonates |
| What do bisphosphonates treat? | hypercalcemia of malignancy (1st line), paget's (1st line), osteoporosis (1st line) |
| What does cinacalcet do? How? | decrease Ca levels via activation of calcium receptor, result: decreased PTH |
| What diseases is cinacalcet used for? | high PTH from carcinoma or renal failure |
| What does plicamycin do? How? | decrease Ca levels, cytotoxic antibiotic interruption of DNA-dir RNA synth (not well understood) |
| What drug causes thrombocytopenia and hemorrhage? | plicamycin |
| What does plicamycin treat? | paget's, hypercalcemia (2nd line) |
| What do thiazides do to calcium balance? How? | Increase Ca levels by Na/K inhibition, decrease Na in lumen, increase Ca/Na basolateral exchange |
| What are thiazides used for (calcium-related)? | hypercalciuria, stones |
| What effects does flouride cause? | increase trabecular bone mass, ohapatite -> fapatite, denser but more brittle |
| What are first line drugs for Paget's? | bisphos, calcitonin (plica - 2nd line) |
| What are drugs used to treat imbalances of chronic renal failure? | vit D, cinacalcet |
| What types of rickets require high-dose vitamin D? | hypophos vit-D resist, vit D-dep type II (receptor mutation) |
First Time Here?
Welcome to Quizlet, a fun, free place to study. Try these flashcards, find others to study, or make your own.