cell cycle
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32 terms
Terms | Definitions |
|---|---|
 s phase | duplication of chromosome (10-12 Hr) |
| M PHASE (mitosis) | separation of DNA/nucleus and separation of cytoplasm (1 hr) |
| interphase | include the phases that prepare cells for growth and division |
| g1 phase | gap phase or growth phase (proteins produced for organelle production) |
| g2 phase | gap phase or growth phase (proteins produced for mitosis) |
| g2M checkpoint | is all DNA replicated? is environment favorable enter mitosis, trigger early mitotic events that lead to chromosome alignment on the spindle in metaphase |
| Metaphase to anaphase transition | are all chromosome attached to the spindle? stimulate sister-chromatid separation, leading to mitosis and cytokinesis |
| start checkpoint | is environment favorable? occurs in late g1 where the cell commits to cell cycle entry and chromosome duplication |
| robust and reliable | the system is ___ in that many assurances are in place to operate under various conditions |
| adaptable | the system is ___ in that it is found in specific cell types and responds to specific signal |
| cyclin | __ forms a complex with cyclin dependent kinase to trigger cell cycle event |
| cdks | _ are inactive with cyclins |
| cyclin dependent kinase | protein kinases that rise and falls as the cell progresses through the cell cycle at specific events |
| cyclins | cdk regulators that must be bound to cdks for activity |
| cyclin-cdk complex | triggers and activates cell cycle events |
| g1/s cyclins | activate cdks in late g1 to trigger progression through start resulting in commitment to cell cycle entry |
| s cyclins | binds cdks after progression through start to help stimulate chromosome duplication |
| m cyclins | activate cdks that stimulate entry into mitosis at g2/m checkpoint |
| g1 cyclin | helps govern activities of the g1/s cyclins which control progression through start in late g1 |
| cki p27 | cdk inhibitor protein, regulate cyclin-cdk complexes by binding to the complex via the cdk active site rendering it inactive |
| g1-cdk | favorable extracellular environment |
| g1/s-cdk and s-cdk | dna damage |
| m-cdk | unreplicated dna and dna damage |
| apc/c | chromosome unattached to spindle |
| CYCLIN D | CDK4, CDK6 |
| CYCLIN E | CDK2 |
| CYCLIN A | CDK1, CDK2 |
| CYCLIN B | CDK1 |
| G1 CDK | CYCLIN D |
| G1/S CDK | CYCLIN E |
| S-CDK | CYCLIN A |
| M-CDK | CYCLIN B |
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