Which binds to same site as Ach on nAchR but activates the receptor initially?
Which phase may be inhibited by cholinesterase inhibitors
Which are cholinesterase inhibitors
neostigmine & pyridostigmine Note: they antagonize neuromuscular blockade (i.e. block breakdown of Ach)
Which has the shortest duration
Note: b/c it's a depolarizing blocker
Which is a longer duration non-depolarizing NMB
Which are the better non-depol b/c they have minimal cardiovascular effects (ie no His release)
vecuronium, pipecuronium, rocuronium,Rapacuronium
What are 3 effects specific to depol blockcade (succinylcholine)
hyperkalemia, myalgia, inc intraocular & intragastric pressure Note: hyperkalemia is rare but potentially fatal cardiac arrest can occur
3 factors altering responses to NMB's
myasthenia gravis, age, burns
Myasthenia gravis (inc or dec) responsiveness to NMB
Note: so give lower dose of NMB
Aminoglycoside antibiotics (enhance or dec) NMB
Note: they do this by dec release of Ach
Succinylcholine is antagonized by ___
What are 3 BDZs
Diazepam, lorazepam, clonazepam
Which is long acting that provides spasmolytic effects and muscular relaxant
Which is intermediate acting and a favorite for older pts
Which is used if confined to bed (very strong)
Which is a GABAb agonist
Intrathecal __ is administered for severe spasticity assoc w/ spinal injury (can cause resp depression)
What cause less hypotension than clonidine but hypotension still possible
Note: dry mouth and drowsiness are side effects
What is commonly used to tx back spasms assoc w/ lower back injury or back strain
In Soma, __ is a sedative-hypnotic that has additive effects mixed w/ alcohol
Note: mixing may result in respiratory depression
What has no central mechanism and works at the sarcoplasmic reticulum
General anesthesia is divided into inhalational and intravenous. Inhalation is divided into halogenated and non-halogenated. The one used today is ___
What are the inhalational agents
-flurane, halothane, N20
BDZ = ___
Others include Ketamine, Etomidate, Propofol
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