Parturition & Lactation (84)

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What secondary messenger system is associated with oxytocin?

IP3/DAG

How do prostaglandins affect uterine smooth muscle?

contraction (via PLC) or relaxation (via cAMP)

What type of hormone is oxytocin?

peptide hormone

Describe the levels of the following hormones during the initiation of the birthing process: progesterone, CRH, estrogen.

decrease in progesterone levels

increase in circulating CRH levels

increase in estrogen levels

How does progesterone affect uterine smooth muscle (3)?

inhibits oxytocin receptor synthesis

stimulates cAMP production

inhibits release of prostaglandins that will excite the uterine smooth muscle

*overall "calming" effect

How does estrogen affect uterine smooth muscle (2)?

ripens cervix

increases number of myometrial gap junctions (makes coordinated and stronger contraction)

Review hormonal changes during pregnancy.

1

What happens to CRH and CRH-binding protein as birth approaches?

CRH increases

CRH-binding protein decreases

What is the purpose of placental secretion of CRH as birth approaches?

increases DHEA-S production

Just prior to birth, what are the 2 distinct sections of the uterus?

upper muscular section

lower thinner section

How does oxytocin affect the placenta?

induces placenta to release prostaglandins, which cause myometrial contractions

What is dystocia?

abnormally slow labor

Name 4 causes of dystocia.

cephalopelvic disproportion

conduction anesthesia

excessive sedation

fetal malposition

What is the major cause of dystocia? Second most common cause?

cephalopelvic disproportion (baby being too large to come out quickly)

excessive sedation

Name 7 hormones that work together to stimulate the growth and maturation of the mammary gland.

estrogens

progesterone

prolactin

hCS

cortisol

insulin

GH

Name 2 hormones involved in deposition of fat tissue in the mammary gland.

estrogens

prolactin

Name 2 hormones that inhibit milk production during pregnancy, and explain how they accomplish this task.

estrogens (prevent terminal differentiation)

progesterone (inhibits lactogenesis)

What action is the main regulator of prolactin secretion during lactation?

suckling

How does suckling affect hypothalamic release of dopamine?

decreases dopamine release

How does suckling affect hypothalamic release of prolactin releasing factor?

stimulates release of PRF

List 3 ways in which prolactin affects lactation.

increase milk production

promotes gene expression of milk proteins

stimulates lactose synthesis

List 3 ways in which prolactin affects reproduction.

decreases GnRH secretion (high levels)

galactorrhea amenorrhea in females/impotence in males

inhibits follicular development during breast feeding

What hormone allows milk to be ejected from the breast?

oxytocin

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