Pathology - Neoplasms (Oncogenes, Tumor Suppressor Genes, Tumor Markers, chemical carcinogens, etc.)
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41 terms
Terms | Definitions |
|---|---|
 abl | Oncogene Gene Product: TK Tumor: CML |
| c-myc | Oncogene Gene Product: TF Tumor: Burkitt's Lymphoma |
| bcl-2 | Oncogene Gene Product: anti-apoptotic molecule Tumor: Follicular and undifferentiated lymphomas (inhibits apoptosis) |
| erb-B2 | Oncogene Gene Product: TK Tumors: breast, ovarian, and gastric carcinomas |
| ras | Oncogene Gene Product: GTPase Tumor: colon carcinoma |
| L-myc | Oncogene Gene Product: TF Tumor: lung tumor |
| N-myc | Oncogene Gene Product: TF Tumor: Neuroblastoma |
| ret | Oncogene Gene Product: TK Tumor: MEN II and III Syndromes |
| c-kit | Oncogene Gene Product: cytokine receptor Tumor: GIST |
| Rb (13q) | Tumor Suppressor gene Gene Product: Rb gene product blocks G1 --> S Tumor: Retinoblastoma, osteosarcoma |
| p53 (17p) | Tumor Suppressor gene Gene Product: p53 gene product blocks G1 --> S Tumor: most human cancers, Li-Fraumeni syndrome |
| BRCA1 | Tumor Suppressor gene Gene Product: DNA repair protein Tumor: breast and ovarian cancer |
| BRCA 2 | Tumor Suppressor gene Gene Product: DNA repair protein Tumor: breast cancer |
| p16 (9p) | Tumor Suppressor gene Tumor: melanoma |
| APC (5q) | Tumor Suppressor gene Tumor: Colorectal cancer (assoc with FAP) |
| WT1 (11p) | Tumor Suppressor gene Tumor: Wilm's Tumor |
| NF1 (17q) | Tumor Suppressor gene Tumor: Neurofibromatosis type 1 |
| NF2 (22q) | Tumor Suppressor gene Tumor: Neurofibromatosis type 2 |
| DPC (18q) | Tumor Suppressor gene Tumor: Pancreatic Cancer |
| DCC (18q) | Tumor Suppressor gene Tumor: Colon Cancer |
| PSA | Tumor Marker Tumor: Prostate Carcinoma |
| Prostatic acid phosphatase | Tumor Marker Tumor: Prostate carcinoma |
| CEA | Tumor Marker Tumor: non-specific (colorectal, pancreatic and others) |
| alpha fetoprotein | Tumor Marker Tumor: hepatocellular carcinoma, nonseminomatous germ cell tumors of the testis |
| beta - hCG | Tumor Marker Tumor: Hydatiform moles, Choriocarcinoma, Gestational trophoblastic tumors |
| CA-125 | Tumor Marker Tumor: ovarian, malignant epithelial tumors |
| S-100 | Tumor Marker Tumor: Melanoma, neural tumors, astrocytomas |
| Alkaline phosphatase | Tumor Marker Tumor: mets to bone, obstructive biliary disease, Paget's disease of bone |
| Bombesin | Tumor Marker Tumor: neuroblastoma, lung and gastric cancer |
| TRAP (tartrate-resistant acid phosphatase) | Tumor Marker Tumor: Hairy Cell leukemia |
| CA-19-9 | Tumor Marker Tumor: pancreatic ADC |
| Calcitonin | Tumor Marker Tumor: thyroid medullary carcinoma |
| Aflatoxins | Hepatocellular carcinoma |
| Vinyl Chloride | Angiosarcoma (liver) |
| CCl4 | centrilobular necrosis, fatty change in liver |
| Nitrosamines | esophagus, stomach |
| cigarette smoke | larynx (SqCC), lung (SqCC and SCC), kidney (RCC), bladder (TCC) |
| asbestos | mesothelioma, bronchogenic carcinoma |
| arsenic | SqCC of skin, angiosarcoma of liver |
| Naphthalene (aniline) dyes | TCC (bladder) |
| Alkylating agents | leukemia |
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