cancer from the epithlial cells
malignant neoplasm of the connective tissue
malignant tumors of lymphocytes
malignant tumors of blood forming tissue and bone marrow
neutrophil count at risk
the lowest level of WBC in the blood following chemo or radiation occurs 10-28 days after dosing.
the study of how various drug forms (liquid, tabs, etc.) determine pharmacokinetics and dynamics. Determine to what extent the drug is absorbed.
what the body does to the drug- involves drug absorptions, distributions, metabolism, and excretion. Used to explain a drug's action in the body, such as its onset, peak, and durations
what drugs does to the body- effects of drugs in the body, both biochemical and physical. Ex. receptor stimulation of a drug and the resulting biologic response
use of a drug to treat a disease. Includes assessment, implementation, monitoring and reassessment.
substance or procedures that prevent or reduce the severity of epileptic or other convulsive seizures
the name given to a drug by the United States Adopted Names Council. Also called the nonpropriertary name. It is not protected by trademark.
the commercial name given to a drug product by its manufacturer, also called the proprietary name.
the name that describes the chemical composition and the molecular structure of the drug
a primary, chronic, neurobiological disease whose developement is influenced by genetic, psychosocial, and enviromental factors. A craving for continued opioid use.
the general term for a state of adaptation in which repetitive exposure to a drug over time induces changes in the drug receptors that reduce one or more of the drugs effect.
drug interactions in which the effect of a combination of two or more drugs with similar actions is equivalent
drug interactions in whcih the effect of a combo of two or more drugs with similar acios is greater thatn the sum of the indevidual effects of the same drugs given alone.
beta adrenergic agoinists (used during the acute phase of asthmatic attacks.
to treat mild to moderate cases of acute asthma
xanthine bronchodilators MOA
increase levels of energy-producing cAMP, competitively inhibiting phosphodiesterase, the enzyme that breaks down cAMP which results in decreased cAMP levels, smooth muscle relaxation, bronchodilator, and increased airflow.
ACE inhibotor SE
Contradindications to Thiazide diuretics
drug interaction with loop diuretic, increase dig effects, sulfa allergy, avoid alcohol
by causing venous dilation, reduces venous return, reduces left ventricular end diastolic volume (preload) results in a lower left ventricular pressure, wall tension is reduced and myocardial oxygen demand is reduced.
slowest to fastest ( PO, topical, SL, Spray, IV) longest duration are PO and topical
sulfonamides major SE
photosensitivity and anaphalaxis
PCN major SE
rash and anaphalaxis, Stevens Johnson syndrome
cephlasporins major SE
rash, anorexia, mild diarrhea
Macrolides major SE
GI effects, hepatotoxicity
tetracyclines major SE
dont give to children under 8 tooth discoloration, bone formation problem
amino glycosides SE
nephrotoxicity and ototoxicity
Black Box Warning ...caution cardiac patients, bone and cartilage development problems
chronotropic effects (positive or negative)
affects the heart rate
used prophylactically to prevent clot formation (thrombus) and an emobolus (dislodged clot)
safer better, thearapeutic levels, non addicting, lower adverse effects, doesnt affect the RR
Anticholerginics in Parkinson's Ds
treats muscle rigidity and and muscle tremors
Rapid Acting Insulins
Human Insulin Aspart, Insulin lispro, Insulin glulsine
Onset Rapid Acting
15 min breakfast tray on floor
Peak Rapid Acting
Duration Rapid Acting
Short acting insulins
humalin r and novalin r
Short acting onset
short acting peak
short acting duration
intermediate acting insulin
Intermediate acting onset
intermediate acting peak
Intermediate acting duration
long acting insulin
lantus ( glargine)
long acting onset
long acting duration
sulfonylreas/ glinides MOA
increase insulin release from beta cells on the pancreas (never combine same MOA)
decrease glucose production in liver, increase muscle glucose uptake, decrease glucose absorption intestine (does not stimulate insulin production)
decrease insulin resistance, decrease glucose production, increase glucose uptake in skeletal muscle, inhibit glucose and triglycerides production in the liver
alpha glycosidase inhibitors
slows carbohydrate absorption and digestion
promotes release of insulin, decreases glucagon secretions, decresase post prandial glucose levels
slows gastric emptying, suppresses glucago secretion
blocks ca channels in the blood vessels leads to vasodilation of peripheal arterioles and arteries of the heart- blocking of the calcium channels in the myocardium, the SA node , and the AV node leaads to a decreased HR----"VND"