module 3

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45 terms

An insulator is also known as a...

boundary element

Recent discoveries on causes of fragile- X syndrome, myotonic dystrophy, and Huntington disease indicate what type of genetic alteration?

expanding trinucleotide repeats

This is the region of a gene where RNA polymerase binds to initiate transcription

promoter

The ______ consists of modifications to histone proteins that affect the expression of DNA sequences.

histone codes

transcriptionalrepression by methylation of DNA is most common in sequences called _____ islands.

CpG

The ____ is a type of _____ protein that binds to a region of DNA in the promoter of a gene called the _____ and prevents _____ from taking place.

repressor, regulatory, operator, transcription

Mutations in the lacI and lacO genes in the lactose system often lead to full production of the three structural genes related to the lac operon even with no lactose available to the organism. Such mutations would be called________.

constitutive mutations

The _________ can be used to quickly screen chemicals for their ability to be mutagenic (and hence potentially carcinogenic).

AMES test

A promoter that affects only genes that are on the same piece of DNA is ____________-acting.

cis

Mutations in the promoter region of the b-globin gene indicate that some areas are more sensitive than others. When mutations occur in consensus sequences (modular elements such as GC box, CAAT box, TATA box) transcription ________________.

decreases

_______________ is also known as RNA silencing and posttranscriptional gene silencing.

RNA interference

A _________________, which binds to a core promoter, consists of general transcription factors and RNA polymerase.

basal transcription apparatus

What human condition is caused by unrepaired UV-induced lesions?

xeroderma pigmentosum

The general term for a protein that binds to an operator.

repressor

A constitutive gene is _______ regulated and is expressed ____________.

not, continually

What symbols are used to describe constitutive mutations in the lac operon?

lacOc, laclc

The process of error correction of mismatched bases carried out by DNA polymerases is called

proofreading

Parts of chromosomes that are not methylated for inactivation, but rather are less dense-staining and are likely active in transcription in the cell.

euchromatin

One type of mutation involves the replacement of a purine with a purine. What general term is associated with this mutational phenomena?

transition

A condition in which a gene or group of genes is expressed all the time.

constitutive

Regions of chromosomes that are inactivated through methylation are termed this.

heterochromatin

A catabolite-activating protein (CAP) exerts _____________control over the lac operon.

positive

The region of a protein that is capable of holding on to a particular nucleotide sequence in order to affect proper gene regulation.

DNA binding domain

The process by which excessive numbers of a sex chromosome are corrected, often by methylating the X chromosome to form a Barr body.

dosage compensation

This term describes genetic elements that affect other elements only when they are located adjacent to them. For example, the operator has this effect on its structural genes.

cis-acting

________act as intermediaries between _______ and specific _____ sequences to modify chromatin structure and activate transcription.

transcriptional activators, chromatin remodeling complexes, DNA

_____________ are complexes where, among other activities, a great deal of RNA degradation takes place.

p bodies

What is the common influence of ultraviolet light on DNA?

dimer formation

This process moves a nucleosome from the TATA box of a gene's promoter so that transcription can occur.

chromatin remodeling

This structure forms when an extra X chromosome is methylated and largely inactivated. It is most commonly found in females.

barr body

These are factors that need not be adjacent to the genes they control. An example would be the lac operon's repressor protein.

trans-acting

mRNAs are degraded by enzymes called ____________.

ribonuclease

Degradation of a eukaryotic mRNA is generally preceded by shortening of the _____________.

poly A tail

When siRNAs are present, the rate of mRNA degradation_____________ and the rate of protein production ___________.

increase, decrease

Proteins that affect chromatin structure without altering histone chemical structure are called _______________.

chromatin remodeling complex

A highly-methylated region of a chromosome that has become largely deactivated and can be seen as dense-regions when viewed using electron microscopy.

heterochromatin

Since the binding of the _________ to the _________ prevents it from binding to _________ by causing a conformational change in its structure, it is called an _________ protein.

inducer, repressor, DNA sequence, allosteric

Apurinic (and apyrimidinic) sites (AP sites) involve a spontaneous loss of ______________ in an intact double-helix DNA molecule

purine

Indicate the level of activity of the lac operon under the medium conditions listed below:

a) No lactose present, no glucose present
b) Lactose present, no glucose present
c) No lactose present, glucose present
d) Lactose present, glucose present
Enter "high" or "off" , separated by a comma, in the order of the a, b, c, d scenarios into the answer box.

off, high, off, off

When regions around genes become sensitive to the enzyme ______________ this is an indication that those regions are becoming ______________ active.

DNAse I, transcriptionally

The ____________________ stabilizes the 5' cap, which must be removed before the mRNA molecule can be degraded from the 5' end.

poly A tail

A eukaryotic DNA sequence that affects transcription at distant promoters is called a(n) ________________.

enhancer

(long answer) Name six different levels at which gene expression might be controlled.

gene structure, transcription, mRNA processing, RNA stability, translation, posttranslational modification

(long answer) List five levels at which gene control can take place in eukaryotes.

chromatin structure, RNA processing, RNA stability, RNA silencing, posttranslational modification

One type of mutation involves the replacement of a pyrimidine with a purine. What general term is associated with this mutational phenomena?

transversion

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