Chapter 12: Inheritance Patterns and Human Genetics

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True or False: A male can produce sperm that contains either X or a Y chromosome.

True

True or False: If an inherited disease is recessive and X-linked, then all males with one copy of the disease-causing gene will have the disease,

True

True or False: In a chromosome map, the percentage of crossing over between 2 genes is equal to the number of map units separating the genes.

True

True or False: The condition that results from the loss of an entire chromosome is called monosomy.

True

True or False: It is possible that a fragment of DNA may become detached from a chromosome and then reattach in the reverse orientation, resulting in a mutation called inversion.

True

True or False: Mutations that result from the substitution of one nitrogen-containing base for another are called deletions.

False. Deletions should be inverse

True or False: Changes in the DNA of an organism are called mutations.

True

True or False: If each parent carries a copy of the sickle cell gene, there is a one-in-four chance that their child will have sickle cell anemia.

True

True or False: Somatic mutations affect an organism's offspring.

False. Affect should be dont' affect

True or False: Mutations usually introduce new chromosomes into the genome of an organism.

False. Usually should be ALWAYS

True or False: Mutations are always harmful.

False. Always should be SOMETIMES

True or False: An individual who expresses a genetic disorder is called a carrier.

False. Genetic disorder should be sec-linked trait

True or False: A pedigree is a family record that shows how a trait is inherited over several generations.

True

True or False: An autosomal trait will occur with equal frequency in both males and females.

True

True or False: the expression of sex-linked genes is controlled by hormones.

False. Hormones should be sex chromosomes

True or False: Down syndrome occurs as a result of nondisjunction of chromosome 21 during meiosis.

True

True or False: Trisomy is the addition or removal of a single nitrogen-containing base.

False

True or False: Nondisjunction results from the failure of replicated chromosomes to seperate during cell division.

True

What are X and Y chromosomes called?

Sex chromosomes

Monosome : nondisjunction ::
A) chromatids : centromere ::
B) male : XY chromosomes ::
C) Haploid : mitosis ::
D) Meiosis : diploid ::

C

Female: XX ::
A) Female : gametes ::
B) Female : Eggs ::
C) Male : YY ::
D) male : XY ::

D

What is the best explanation for the observation that females rarely get the disease hemophilia?

A female could only get the disease by having a mother who is a carrier and a father who has the disease. Since most males with the disease do not survive to reproductive age, this is an extremely unlikely event.

Which of the following is NOT true of chromosome maps?
A) They depict the linear sequence of genes on a chromosome
B) They are constructed using crossing-over data from mating experiments
C) They depict absolute differences between genes on a chromosome
D) They are practical with species having only a few chromosomes

C

A mutation caused by a piece of DNA breaking away from its chromosome and becoming attached to a non homologous chromosome is called what?

Translocation

A change in a gene due to damage or being copied incorrectly is called what?

A mutation

Are the effects of mutation helpful, harmful, or neutral?

All of the above

A diagram in which several generations of a family and the occurrence of certain genetic characteristics are shown is called a what?

Pedigree

A family record that indicated the occurrence of a trait is called a what?

Pedigree

Which of the following traits in controllable by multiple alleles in humans?
A) Sickle cell anemia
B) Blood type
C) Hemophilia
D) Pattern baldness

B

What would be the blood type of a person who inherited an A allele from one parent and an O allele from the other?

type A

Which of the following describes hemophilia?
A)Multiple-allele trait
B) Dominant trait
C) Sex-linked trait
D) Codominant trait

C

In humans, the risks of passing on a genetic disorder to one's child can be assessed by what?

Analysis of a pedigree, Prenatal testing, and genetic counseling

Genetic counseling is a process that does what?

Helps identify parents at risk for having children with genetic disorders, assists parents in deciding whether or not to have children, and uses a family pedigree.

While studying several generations of a particular family, a geneticist observed that a certain disease was found equally in males and females and that all children who had the disease had parents who also had the disease. The gene coding for this disease is probably?

Autosomal dominant

If both parents carry the recessive allele that causes custic fibrosis, the chance that their child will develop the disease is what?

One in four.

If a characteristic is sex-linked, it:
A)Occurs most commonly in males
B) Occurs only in females
C) Can never occur in females
D) Is always fatal

A

Since the allele for colorblindness is located on the X chromosomes, colorblindness:
A) Can't be inherited
B) Occurs only in adults
C) is sex-linked
D) None of the above

C

How many chromosomes do people with down syndrome have?

47 chromosomes

Trisomy is a mutation that results in a cell having an extra what?

Chromosome

What happens when nondisjunction occurs?

A gamete will receive too many or too few homologues of a chromosome

In humans the genotype XX, results in a _______.

Female

Linked genes can be separated from eachother in meiosis if ___________ occurs.

Crossing-over

When traits do not appear according to the expected ratio in offspring, ________ may have occured.

Crossing-over

When a piece of chromosome attaches itself to a nonhomologous chromosome, the resulting mutation is called a ________.

Translocation

A mutation in which a piece of chromosome is lost during meiosis is called a ___________.

Deletion

A change in an organism's DNA is called a _______________.

Mutation

Spontaneous changes in genetic material are called _________________.

Mutations

Identifying patterns of inheritance within a family over several generations is possible by studying a diagram called a ___________.

Pedigree

___________ technology is making it possible to cure genetic diseases.

Gene

A person who is herterozygous for a recessive disorder is called a ____________.

Carrier

By studying a _________, genetic counselors can study how a trait was inherited over several generations.

Pedigree

A genetic disorder resulting in defective blood clotting is _____________.

Hemophilia

A genetic disorder in which an individual lacks and enzyme responsible for converting the amino acid phenylalanine into the amino acid thymine is called __________________________.

PKU, phenylketonuria

A trait that is determined by a gene that is found only on the X chromosome is said to be _________________.

sex-linked

In humans, the genetic disorder caused by an extra chromosome 21 is called ____________.

Down syndrome

The failure if replicated chromosomes to separate is called ______________.

Nondisjunction

What are X-linked genes?

Genes found on the X chromosome

What are Y-linked genes?

Genes found on the Y chromosome

What is sex lineage?

The presence of a gene on a sex chromosome

What are linkage groups?

The group of genes located on one chromosome

What is a chromosome map?

A diagram that shows the linear sequence of genes on a chromosome

What are 3 different types of mutations?

Germ-cell mutations, somatic mutations, and lethal mutations

Where so germ-cell mutations occur?

They occur in an organism's germ cells (gametes), do not affect the organism

What are somatic mutations?

Mutations that take place in an organism's body cells and can therefore affect the organism

What are lethal mutations?

Mutations that cause death, often are before birth

What are chromosome mutations?

Mutations that either are changes in the structure of a chromosome or the loss of an entire chromosome

What's a deletion?

Is the loss of a piece of chromosome due to chromosomal breakage

What is an inversion?

Is a chromosome mutation in which a chromosomal segment breaks off and then reattaches in reverse orientation to the same chromosome

What is translocation?

Is a chromosome mutation in which a chromosome piece breaks off and reattaches to another, non homologous chromosome

What may gene mutations involve?

large segments of DNA or a single nucleotide within a codon

What is a point mutation?

Is the substitution, or removal of a single nucleotide

In point mutations, what are substitutions?

When one nucleotide in a codon is replaced with a different nucleotide, resulting in a new codon

What causes the genetic disorder of sickle cell anemia?

Caused by a point mutation that substitutes adenine for thymine in a single DNA codon. This substitution results in a defective form of the protein hemoglobin

What is a frame-shift mutation?

When an addition or deletion of a single nucleotide causes the remaining codons to be incorrectly grouped

What are genetic disorders?

Are diseases or debilitating conditions that have a genetic basis

What are single-allele traits?

Traits that are controlled by a single allele of a gene

What is Huntington's disease?

Disease caused by a dominant allele located on an autosome and is therefore said to show an autosomal-dominant pattern of inheritance

What is a genetic marker?

Is a short section of DNA that is known to have a close association with a particular gene located nearby

What are multiple-allele traits?

Traits that are controlled by three or more alleles of the same gene that code for a single trait

What is an example of something that is controlled by 3 or more alleles?

the ABO blood groups

What are polygenic traits?

A trait that is controlled by 2 or more genes

What are some examples of polygenic traits?

Skin color, eye color, human height, foot size

What are 3 X-linked traits?

Colorblindness, hemophilia, and Duchenne muscular dystrophy

WHat is Duchenne muscular dystrophy?

a form of muscular dystrphy that weakens and progressively destroys muscle tissue

What is a sex-influenced trait?

A trait with the presence of male or female sex hormones, which influence the expression of certain human traits

In a sex-influenced trait, do males and females have the same or different phenotypes?

Different.

What is monosomy?

Is when a zygote with 45 chromosomes have only one particular copy of a chromosome

What is trisomy?

Is when a zygote with 47 chromosomes have three copies of a particular chromosome

Are abnormalities with chromosomal numbers lethal

Yes, they often are

What is genetic screening?

Is an examination of a person's genetic makeup

What is genetic counseling?

A form of medical guidance that informs them about problems that could affect their offspring

What happens during amniocentesis?

The physician removes a small amount of amniotic fluid from the amnion. Then about 16 weeks into the pregnancy, fetal cells and proteins can then be analyzed and a karyotype can also be prepared

What happens during choronic villi sampling?

physician takes a sample of the chorionic villi. The villi will soon have the same genetic makeup as the fetus. Tissue samples from the villi can then be used to produce a karyotype

What is PKU?

A genetic disorder in which the body cannot metabolize the amino acid phenylalanine. This then causes severe brain damage

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