Chemical Mediators of Inflammation
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6 terms
Terms | Definitions |
|---|---|
 Histamine | Early mediator; dilates arterioles, constricts large arteries and bronchioles, increases vascular permeability |
| Platelet Activation Factor | vasodilator, increases vascular permeability, promotes leukocyte aggregation and activation, chemotactic, activates platelets, stimulates oxidative burst and arachidonic acid derivativse |
| Interleukin-1 | enhances histamine release, increases PGE2 production for fever, activates endothelium/leukocytes/fibroblasts, stimulates production of other cytokines and acute phase proteins |
| Tumor Necrosis Factor-alpha | activation and aggregation of neutrophils, activates endothelium/leukocytes/fibroblasts, appetite suppression, leukocyte release from bone marrow, ACTH release, stimulates production of other cytokines and acute phase proteins. Mediator of septic shock and DIC |
| Interleukin-6 | stimulates production of acute phase proteins, induces fever, B cell growth factor, inhibits TNF-alpha production |
| Nitric Oxide | vasodilation, reduced platelet aggregation and adhesion, inhibits leukocyte adhesion, forms antimicrobial reactive species, very localized effect |
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