USMLE step 1 Rx interactions
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43 terms
Terms | Definitions |
|---|---|
 atropine like a/e | TCA, low potency neuroleptics, 1 gen antihistamines, amantadine |
| coronary vasospasm | cocaine, amphetamine, sumitryptan, ergotamine |
| cutaneous flushing | VANC: vancomycin, adenosine, niacin, CCB (dihydropyridine) |
| dilated CMP | doxorubicin (adriamycin). daunorubicin |
| torsades de pointes | Class III (sotalol), class Ia (quinidine) antiarrhythmics, haloperidol, resperidone, methadone, metoquinine, chloroquinine, macrolide, HIV protease inhibitors |
| agranulocytosis | clozapine (atypical antipsych), carbamezapine, colchicine, propylthiouracil, methimazole, dapsone |
| aplastic anemia | chloramphenicol, benzene, NSAID, propylthiouracil, methimazole |
| direct coomb + hemolytic anemia | methyldopa |
| Gray baby syndrome | chloramphenicol |
| hemolysis in G6PD deficient pts | IS PAIN For Docs: Fava beans, dapsone isoniazid, sulfonamides, primaquine, aspirin (high dose), ibuprofen, nitrofuratoin, naphthaline |
| megaloblastic anemia | phenytoin, methotrexate, sulfa rx |
| thrombotic complications | OCP + smoking |
| thrombocytopenia | herapin (HIT), H2 blockers |
| cough | ACE inh |
| pulmonary fibrosis | Bleomycin, amioderone, busulfan |
| acute cholestatic hepatitis | macrolide- erythromycin estolate |
| focal massive hepatic necrosis | halothane, acetaminophen, valproic acid, amanita phalloides (cap mushroom) |
| hepatitis | isoniazid |
| pseudomembranous colitis | clindamycin, ampicillin |
| adrenocortical insufficiency (3rd) | glucocorticoid withdrwal (low CRH, low ACTH, low cortisol) |
| gynecomastia | some drugs create awesome knockers: spiroloactone, digitalis, cimentidine, alcohol (chronic use), ketoconazole, marihuana |
| hot flashes | tamoxifen, clomiphene |
| hypothyroidism | lithium, amiodarone |
| gingival hyperplasia | phenytoin |
| gout | furosemide, thiazide |
| osteoporosis | corticosteroids, herapin |
| photosensitivity | sat for a photo: sulfonamides, amioderone, tetracycline |
| rash (stevens-johnson syndrome) | Ethosuximide, lamotrigine, carbamezapine, phenobarbital, phenytoin, sulfa rx, penicillin, allopurinol |
| SLE- like syndrome (high anti-histone ABx) | SHIPP: sulfonamides, hydralazine, procanamide, phenytoin |
| tendonitis, cartilage damage | fluoroquinolones |
| fanconi's syndrome | expired tetracycline |
| intertitial nephritis | methicillins, NSAIDs, furosemide (loop) |
| hemorrhagic cystitis | cyclophosphamide, ifosfamide (prevent w/ mesna) |
| cinchonism | quinidine (anti-arrhythmic), quinine (anti-malaria) |
| diabetes insipidus | Li, demeclocycline (ADH-R antagonist) |
| parkison-like syndrome | haloperidol, chlorpromazine (atypical anti-psych), reserpine, metoclopramide (anti-emetic) |
| seizures | bupropion (atypical antidep) imipenem/cilastatin, isoniazid |
| tardive dyskinesia | antipsychotics |
| disulfiram-like rx | provar cerveza me hace sufrir: procarbazine (chemo), cephalosporins (1st gen), metronidazole, antibuse, sulfonylureas |
| nephrotoxic & neurotoxic | polymyxins |
| nephrotoxic & ototoxic | aminoglycosides, vancomycin, loop diuretics, cisplatin |
| P450 inducers | BCG PQRS: barbituates, carbamezepine, chronic alcohol, griseofulvin, phenytoin, quinidine (anti-arrhythmics), rifampin, st. john's worth |
| P450 inhibitors | PICK EGS: protease inhibitors, isoniazid, cimetidine, ketoconazole, erythromycin, grape fruit juice, sulfonamides. acute alcohol |
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