| Term | Definition |
|---|
| MOA of Tetracyclins | REVERSIBLY binds 30S s/u - prevents aminoacyl tRNA to acceptor site on mRNA - inhibits bacterial protein syn |
| Tetracyclins bactericidal or static | STATIC |
| Admin & metab of Tetracyclins | oral & parental, excreted by kidney; dose adj for renal insufficiency; concentrated in liver; excreted in BILE |
| Admin & metab of Doxycycline | long t 1/2 (qid/bid) hepatobiliary and fecal excretion; no dose adj |
| What shortens T 1/2 of Doxycycline | concurrent barbiturates, phenytoin, dilantin |
| Indications for tetracyclines | rickettsial, CHLAMYDIAL infections (pneumonia (twar), psittacosis, urethritis); alt to macrolides for mycoplasma pneumonia; early lyme disease; lymphogranuloma (some tets MRSA, PRSP, VRE) vererum; bronchitis; cholera, tropical sprue, brucellois, blind-loop s/o; ACNE |
| Adverse reactions to tetracyclines | GI irritation, photosensitivity (not doxcycline), hepatic toxic (esp preggers), uremia (older), renal tubular acidosis (outdated older tets); adverse effects on bone/teeth (bind to phosphates); C.difficile enterocolitis (gave pt metronidazole instead) |
| Contra of tetracyclines | Pregnant womens - CROSSES placenta - acute fatty necrosis and adverse bone/teeth effects in fetus |
Combine with other sets
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