Protein Synthesis Inhibitors, Aminoglycosides, Tetracyclines, Chloramphenicol

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Protein synthesis inhibitors: buy AT 30 and CCELL at 50

1. Aminoglycosides
2. Tetracyclines
3. Chloramphenicol
4. Clindamycin
5. Erythromycin and Macrolides
6. Linezolid
7. Lincomycin

What are the toxicity of aminoglycosides?

1. Nephrotoxicity
2. Ototoxicity
3. Teratogen
Along with vancomycin

Which drugs have nephrotoxicity and ototoxicity?

1. Aminoglycosides
2. Vancomycin
3. Cisplatin/Carbaplatin
4. Loop diuretics

When on tetracyclines or fluoroquinolones, what must the patient avoid in his/her diet?

1. Milk
2. Antacids,
3. Iron containing preparations
B/c divalent cations inhibits the uptake of tetracyclines (absorption in gut)

What are tetracyclines used to treat? (Mnemonic)

VACUUM THe BedRoom
1. Vibrio cholera
2. Acne
3. Chlamydia
4. Ureaplasma urealyticum
5. Mycoplasma
6. Tularemia
7. H. pylori
8. Borrelia burgdorferi (lyme)
9. Rickettsia

What are macrolides used to treat? (Mnemonic)

PUS
Atypical Pneumonia: Chlamydia pneumonia, chlamydia psittaci, mycoplasma, legionella
Upper Respiratory Infection: Strep pyogenes, Strep pneumo
STDs: Chlamydia, N. gonorrheae

What is chloramphenicol used for?

1. Meningitis by H. influenza, N. meningiditis, S. pneumonia

What are the toxicities of chloramphenicol

1. Anemia
2. Aplastic anemia
3. Gray baby syndrome in premature infants b/c those infants lack a mature UDP-glucuronyl transferase.

Which drugs are used to treat pseudomonas?

1. Polymyxins
2. Fluoroquinolones
3. Extended spectrum: Ticarcillin, carbenicillin, piperacillin.
4. 3rd/4th generation cephalosporins
5. Aztreonam

Which antibiotic is confined to topical use because of nephrotoxicity?

Neomycin of the aminoglycocides.

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