| Term | Definition |
|---|
| Tetracyclines | Demeclocyline, doxycycline, minocycline, tetracycline Bacteriostatic, broad spectrum, 30 S |
| Tetracycline MOA | Enters during rapid phase thru passive diffusion (tetracycline) or lipid cell wall (doxycycline). Binds 30 S Subunit |
| Tetracycline Resistance | Plasmid mediated, decrease inclux or increase efflux, alter binding at the ribosome |
| Tetracycline absorption | Stomach and Upper GI. Chelation-dairy products will decrease absorption. Doxycycline has better absorption and less chelation (100mg/12-24 hrs). Parental, topical and opthalamic |
| Tetracycline Distribution | MOst body fluids including CSF. Minocycline in tears and saliva-used for meningiococcus tx. In spleen, bone marrow as well-watch for chelation in bone (don't use in growing children or pregos) Pregnancy category D |
Combine with other sets
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