Unknown Facts in DIT Immunology
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25 terms
Terms | Definitions |
|---|---|
 CD Surface Marker:found on all NK cells and macrophages | CD16 |
| CD Surface Marker: inhibits compliment C9 binding | CD55/59 aka decay accelerating factor Mutation or absent in Paryoxysmal Nocturnal Hemoglobinuria |
| Cytokine: growth and activation of eosinophils | IL-5 |
| VDJ recombination is initiated by what gene? | Recombination activating gene complex (RAG) RAG-1 and RAG-2 Mutations in RAG arrest B and T cell development |
| Immunoglobulin: 75% of the immuniglobulin pool | IgG |
| Immunoglobulin: occurs as a dimer | IgA |
| Immunoglobulin: Primarily intravascular, early Ig response | IgM |
| Immunoglobulin: distributed evenly intravascular and extravascularly | IgG |
| Immunoglobulin: can be a pentamer | IgM |
| What happens when you are deficient in CD55/59? | paroxysmal nocturnal hemoglobinuria no DAF, meaning complement lyses own red blood cell Results in iron deficiency anemia |
| Symptoms of paroxysmal nocturnal hemoglobinuria What is Ham's Test? Treatment for PNH? | hemosiderinuria chronic intravascular hemolysis thrombosis + Ham's test (RBC's lyse at low pH) Rx: Iron + warfarin, bone marrow transplant |
| Erythoroblastosis Fetalis? | Maternal anti Rh-D antigen to baby Results in hemolysis of the newborn Can lead to hydrops fetalis, IU death Tx: Anti-Rh-D immunoglobulin |
| Type of hypersensitivity: PSGN - Asthma - Polyarteritis nodosa - ABO Blood incompatibility - Eczema - | Type of hypersensitivity: PSGN - 3 Asthma - 1 Polyarteritis nodosa - 3 ABO Blood incompatibility - 2 Eczema - 1 |
| What is serum sickness? | Immune complex disease type III antibodies to foreign proteins produced (takes 5 days) Immune complex deposit into membranes and fix complement leading to tissue damage Sx - fever, urticaria, arthralgia, proteinuria, lymphadenopathy |
| Arthus reaction? | Local type III hypersensitivity Intradermal injection of antigen induces antibodies Sx - edema, necrosis, activation of complement Often following vaccinations |
| Conditions with elevated ESR | Disease activity in RA/SLE Polymyalgia rheumatica temporal arteritis infection/inflammation malignancy |
| Young child with tetany from hypocalcemia, candidiacsis from immunosuppression What cell type is deficient? | Digeorge - T cells |
| Child has immune disorder -> repeated staph. abcesses -> neutrophils fail to respond to chemotactic stimuli | Job Syndrome (Hyper IgE) Deficiency in IFN-g because PMNs fail to respond to C5a/LTB4 |
| IgA deficiency, poor smooth pursuit with eyes telangiectasias of face Increased lymphoma leukemia risk Increased AFP | ataxia-telangiectasia |
| Chediak Higashi Disease | Defective LYST gene (lysosomal transport) Giant cytoplasmic granules in PMNs diagnostic Triad - partial albinism, neurologic disorders, recurrent respiratory tract and skin infections |
| Child with Eczema, cold s. aureus abscesses, coarse facial features, 2 rows of teeth | Job's Syndrome |
| Child with thrombocytopenia, eczema, recurrent pyogenic diseases | Wiscott Aldrich syndrome also decreased IgM, increased IgA |
| NADPH Oxidase deficiency results in susceptibility to what diseases? | Catalase+ organisms S. Aureus, pseudomonas, E. Coli Aspergillus, Klebsiella, Candida |
| Patient suffers from recurrent neiserria infections What is deficient? | C5-C9 no membrane attack complex (MAC) |
| After bone marrow transplant, patient suffers dermatitis, enteritis, hepatitis - diagnosis? | Graft vs. Host disease |
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