NAME: ________________________

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5 Written Questions

5 Matching Questions

  1. Decr phase 4 rt in pacemaker cells is caused by ___
  2. Digitalis has a pos inotropic effect. It inhibits ___ on the myocardial cell membrane.
  3. PS (ACh) via muscarinic receptors decr atrial contractility by ___.
  4. In working myoctes, phase 0 of AP is rapid depol caused by ___
  5. I(f) is turned on by ___.
  1. a repol of memb potential in preceding AP.
  2. b Na+, K+ -ATPase (causing incr [Na+](intracel))
  3. c I(Na)
  4. d decr inward Ca2+ current in plateau
  5. e decr I(f)- the inward Na+

5 Multiple Choice Questions

  1. • incr Ca2+ conductance- inward
    • note that this is different; I(Na) in working myocytes
  2. Norepi
  3. • 1º incr K+ out
    • decr Ca2+ in
  4. diminishing Na+ gradient, which diminishes Na+-Ca2+ exchange
  5. incr

5 True/False Questions

  1. Incr afterload causes ___ SV. It is manifest as incr aortic presincr


  2. Muscarinic receptor activation causes ___ in the CV, splanchnic, and skeletal vascular smooth muscle constriction


  3. Alpha-1 receptor activation causes ___ In the CV system.• positive chronotropy
    • pos dromotropy
    • pos inotropy


  4. In nodal pacing myocytes, phase 4 is slow repol (diastolic depol) caused by ___.• I(f)- inward Na+


  5. Neg dromotropy reduces AV nodal conduction velocity by ___decr rt of phase 4 depol in pacemaker cells


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