Diabetes Oral Drug/Insulin Doses

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initial dosing, dose adjustments, brand names

Metformin

Glucophage
500mg BID

Glimepiride

Amaryl
1-2 mg/day

Glipizide

Glucotrol
5 mg/day

Glyburide

Diabeta, Micronase
5 mg/day

Pioglitazone

Actos
15 mg/day

Rosiglitazone

Avandia
2 mg/day

Exenatide

Byetta
5 mcg BID

Sitagliptin

Januvia
100 mg/day
CrCL 30-50 (50 mg/day), CrCL <30 (25 mg/day)

Insulin total daily dose

0.5 - 0.6 mg/day

Insulin basal dose

40-50% (NPH, Glargine, Detemir, Lantus)

Insulin bolus dose

50 - 60% (Regular, Aspart, Lispro)

Insulin short acting switch to rapid acting

use 80% of short acting dose (decrease by 20%)

Insulin BASAL dose adjustment

only based on fasting glucose correction
50 / unit insulin (popl'n) or 1800 / total units insulin (indv)

Insulin BOLUS dose adjustment

decide based on prandial glucose
calculate based on fasting glucose and carb coverage
carbs: 12-15 / unit insulin (popl'n) or 450 / unit insulin (indv)

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