IPAP Microbio Exam 5 Leishmania
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Created by:
docbarber4 Plus on July 19, 2011
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16 terms
Terms | Definitions |
|---|---|
 Leishmania present three clinical pictures, cutaneous, visceral, and muco-cutaneous. Each of these are associated with their own genus and species. Name the genus-species associated with each clinical presentation. | Leishmania tropica - cutaneous leishmaniasis Leishmania braziliensis - mucocutaneous leishmaniasis Leishmania donovani - visceral leishmaniasis |
| Name the vector for leishmaniasis. | Sandflies |
| What is a common name of cutaneous leishmaniasis found in Iraq? | Badhdad Boil |
| Which cells are parasitized by leishmania? | Cells of the reticulo-endothelial system, macrophages. |
| True/False. Leishmania infections are easily diagnosed with a simple blood smear. | False. Traditional diagnosis has been Giemsa stained tissue smears, and skin scrapings. |
| True/False: Cattle and sheep are the reservoir hosts of Leishmaniasis. | False. Dogs and rodents are important reservoir hosts of Leishmania. |
| What is the name of the flagellated stage of the leishmania parasite that is injected when the vector takes a blood meal? | The promastigote (from mastix meaning whip - flagella in this case) is injected by the vector. |
| What is the name of the stage of the leishmania parasite that is taken up by macrophages of the reticuloendothelial system? | Amastigotes are found in the macrophages. (From mastix, meaning whip - flagella in this case). This form is without flagella thus the name amastigote - without whip or flagella. |
| If a soldier presents with a skin lesion that is difficult to heal, and the soldier has a travel history that includes a recent deployment to Iraq, what parasitic disease might you add to your differential diagnosis? | Cutaneous leishmaniasis. |
| What would be the specimen of choice for diagnosis of cutaneous leishmaniasis? | Skin scrapings. |
| Name the three clinical presentations of leishmania and the genus and species associated with each. | Leishmania tropica - cutaneous leishmaniasis Leishmania braziliensis - muco-cutaneous leishmaniasis Leishmania donovani - visceral leishmaniasis |
| Name the 3 species of leishmania | Leishmania donovani Leishmania tropica, Leishmania major Leishmania braziliensis |
| Intermediate host of leishmania | Phlebotomine sandflies (Leishmania - intracellular protozoa) |
| Stages and location in man of leishmania | Promastigotes macrophages Amastigotes tissue cells (inclu macrophages) |
| Clinical manifestations of cutaneous leishmania | Cutaneous Leishmaniasis: one or morelesions following sandfly feeding; range in size and appearance over time; look like a volcano, with raised edge and central crater; develops scab, can be painful or painless; some have swollen glands near sores |
| Clinical manifestation of visceral leishmania | Visceral Leishmaniasis: manifests with fever, weight loss, enlarged spleen/liver (spleen larger than liver), some have swollen glands; blood tests may be abnormal (i.e. low RBC and WBC and platlets); can be opportunisitic infex of HIV |
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