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The scientist who received the first Nobel Prize in medicine for his work on antibody therapy was

VON BEHRING

Proteins that react specifically with the chemical structures in the antigen that induces them are called

ANTIBODIES

Antibodies are made by

BCELLS AND PLASMA CELLS

T cells primarily are responsible

CELL-MEDIATED IMMUNITY

Secondary lymphoid organs

are strategically located in the body AND facilitate interactions between cells

Epitopes or antigenic determinants

are a portion of antigen recognized by antibody AND may be approx. 10-25 amino acids in length

The humoral immune response involves the manufacture and use of

ANTIBODIES

Which of the following is not typical of an antigen

LOW MOLECULAR WEIGHT

Specific chemical groups on an antigen molecule to which the immune response is directed are

ANTIGENTIC DETERMINANTS

Generally antigenic molecules usually have molecular weight greater than

10,000 DALTONS

Which of the following is/are secondary lymphoid organ(s)?

SPLEEN AND LYMOH NODES

A term synonymous with antibody is

IMMUNOGLOBIN

Which of the following do not induce a strong immune response

LIPIDS AND NUCLEIC ACIDS

There are __ classes of antibody

5

Which of the following antibodies is a pentamer?

IGM

The chains of an antibody molecule are bonded to one another by

DISULFIDE BONDS

Which of the following antibodies is a dimmer?

IGA

The immunoglobulin monomer conists of

2 HEAVY AND 2 LIGHT CHAINS

Which class of antibody accounts for the bulk of the circulating antibody

IGG

The characteristic function and properties of each class of antibody is determined by the

CONSTANT REGION AND HEAVY CHAIN

An IgG molecule has two

HEAVY CHAINS, LIGHT CHAINS & ANTIGEN BINDING SITES

Antigens interact with antibodies at

AT THE OUTER END OF EACH ARM OF Y

The Fc region on IgG

INTERACTS W THE COMPLEMENT

How long after initiation of a primary response do significant amounts of antibody appear in the blood?

10-14 DAYS

The only class of antibody that can cross the placenta is

IGG

Which is the first antibody class made during the primary response to an antigen?

IGM

Which of the following is the most abundant immunological class produced?

IGA

Which is the most efficient at intitating the classical pathway of the complement cascade?

IGM

Which of the following class of antibody is primarily found in external secretions?

IGA

The function of the secretory component of the IgA molecule is

to protectc IGA from being destroyed by proteolytic enzymes.

The immunoglobulin that is important in hypersensitivity reactions is

IGE

According to the clonal selection theory

EACH B CELL IS ALREADY PROGRAMMED TO PRODUCE A CERTAIN ANTIBODY

"Clonal selection" and "clonal expansions"

ALL OF THE ABOVE

Tcells and B cells are manufactured in the

BONE MARROW

T cells mature in the

THYMUS

The cells that actually secrete antibodies are

PLASMA CELLS

CD4 cells are often

T HELPER CELLS

CD8 cells are often

T CYTOTOXIC CELLS

Antigens may be processed for presentation by

MACROPHAGES & DENDRITIC CELLS

Macrophages and dendritic cells are

ANTIGEN PRESENTING CELLS

Only antigen presenting cell

PRODUCE MHC CLASS II MOLECULES

It would be useful if antigens were delivered directly to

PEYERS PATCHES & MCELLS

Class II MHC molecules are found primarily on

MACROPHAGES & DENDRITIC CELLS

The stimulation of B cells to divide and mature is provided by T

T HELPER CELLS

peptides presented by MHC class II peptide molecules are

EXOGENUS ANTIGENS

T-independent antigens

POLYSACCHARIDES

The surface receptors on B and T cells both

VARIABLE & CONSTANT REGION

Which is involved in reacting to virus -infected cells?

Cell-mediated immunity, Tcytoxic cells AND MHC I

Perforin is produced by

NK CELLS

Giant cells are

USED TO CONTAIN BACTERIAL INFECTIONS

Apoptosis is a

form of cell suicide AND is induced in target cells by effector T cytotoxic cells.

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