Mitosis and Meiosis

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Define "mitosis"

cell division

Define "interphase"

the time during which chromosomes replicate

Why is interphase called the "resting stage"?

the cell is not actively dividing

Define "centromere"

each chromosome and the duplicate piece of DNA that was just made are held in the center by this region

Define "chromatid"

the individual chromosomes in the "whole chromosome" after interphase

How many chromosomes does the cell have?

we still describe the cell as having 46 chromosomes, each consisting of two chromatids

Define "prophase"

the first step of mitosis

Describe the process of "prophase"

the centrioles move away from each other to opposite sides of the cell, form a bunch of fibers (mitotid spindle) that attach to the chromosomes at their centromeres and help to push/pull them around during mitosis, chromosomes condense, and nuclear membrane begins to break up

Define "mitotic spindle"

a bunch of fibers formed by centrioles in metaphase

Define "metaphase"

the second step of mitosis

Describe the process of metaphase

the chromosomes line up (moved by spindle fibers) at the equator of the cell

Define "metaphase plate"

the equator of the cell

Define "anaphase"

the third step of mitosis

Describe the process of anaphase

the centromere that joins each pair of chromatids splits in two so that each chromatid separates from its partner (each chromatid now chromosome); newly separated chromosomes move toward opposite poles of the cell; the cell physically begins splitting in two

Define "cleavage furrow"

the area where it pinches inward (when the cell splits in two)

Define "telophase"

the fourth step of mitosis

Describe the process of telophase

a nuclear membrane forms in each new cell and two daughter cells result (each 46 chromosomes); then divides in cytokinesis

Define "cytokinesis"

the process where the cytoplasm divides

What happens after a cell undergoes mitosis?

the two daughter cell that it produces enter interphase

What is the "one-gene-one-protein" theory?

each gene corresponds to a single protein; when we say "gene," referring to some portion of a chromosome that gives rise to one protein molecule

Define "gametes"

sex cells

Define "haploid"

cells that have only one set of chromosomes

Define "meiosis"

a special type of cell division necessary for sexual reproduction

Define "zygote"

the cell formed when the sperm fertilizes the ovum

What happens during meiosis?

1. cell undergoes DNA replication during interphase; all chromosomes replicate and left with a cell that still has 46 chromosomes each made up of two chromatids joined by a centromere
2. replicated chromosomes are split up in the course of two sets of divisions: prophase I, metaphase I, anaphase I, telophase I, and prophase II, metaphase II, anaphase II, and telophase II
3. the differences between mitosis and meiosis found during the first set of divisions

Describe "Meiosis I"

the first set of four phases: prophase, metaphase, anaphase, and telophase I; chromosomes already replicated and found as two chromatids held together at the centromere

What is the difference between Meiosis I and the four phases of mitosis?

at the very beginning, homologous chromosomes pair up in a process called synapsis

Describe "prophase I"

synapsis occurs; all chromosomes have to find their homologous partner and pair up, longest phase of meiosis; spindle formed, chromosomes condense, nuclear membrane disintegrates

What happens after synapsis (Prophase I)?

"crossing over" takes place, where the like segments on homologous chromosomes are exchanged

Define "tetrad"

because each pair of replicated chromosomes consists of four chromatids (two chromatids per replicated chromosome , and two replicated chromosomes) it can be called a "tetrad"

Describe "metaphase I"

the chromosomes line up on the equator of the cell; chromosomes stay in their homologous pairs

Describe "anaphase I"

unlike anaphase of mitosis, the centromeres in meiosis do not divide; instead, homologous pairs separate, with one entire replicated chromosome (a pair of chromatids and a centromere) moving to opposite poles of the cell

Describe "telophase I"

the two cells finish cytokinesis and nuclear membranes reform around the chromosomes

What is the result of "telophase I"?

because there are no homologous pairs (only 23 replicated chromosomes) the cells are considered haploid

What is the difference between Meiosis I and Meiosis II?

in meiosis I, we start off with 46 chromosomes, but in meiosis II, we start off with 23 chromosomes

Describe Meiosis II.

prophase II, spindle forms, nuclear membrane disintegrates, DNA condenses, but not pairing of chromosomes this time; metaphase II, chromosomes line up individually along equator; anaphase II, centromere splits and the chromatids divide (called chromosomes again); telophase II, nuclear membrane forms around the newly split chromosomes and left with four haploid cells

What happens to the haploid cells after telophase II?

the four haploid cells do not replicate any further unless fertilization triggers new cell cycles

Define "gametogenesis"

the formation of sperm and ova

What is the term for "the formation of sperm"?

spermatogenesis

Define "spermatogonium"

a diploid cell at the start of spermatogenesis

What do spermatogonia live in?

tiny tubules called seminiferous tubules (located in testes; male gonads)

Describe the first three steps of "spermatogenesis"

1. spermatogonium replicates all chromosomes during interphase (46 chromosomes) and each chromosome is made of two chromatids joined by a centromere
2. cell undergoes prophase I, homologous chromosomes undergo synapsis and crossing over occurs
3. cell undergoes metaphase I where paired chromosomes lind up on spindles at the equator; two centromeres on each spindle fiber

Describe the next two steps of "spermatogenesis" after the first three steps.

4. cell undergoes anaphase I, but the centromeres don't divide; homologous chromosome pairs separate
5. cell finishes dividing during telophase I and now have two cells; each cell 23 chromosomes and each chromosome made up of two chromatids still joined by centromere; cells are haploid

Describe the last step of spermatogenesis

6. each of cells then go through meiosis II; chromosomes condense but do not pair up during prophase II; line up individually along spindle fibers during metaphase II, centromeres divide during anaphase II, cells finish telophase II and have four cells of 23 unreplicated chromosomes (haploid)

How often does spermatogenesis occur?

occurs on a daily basis, beginning at puberty and lasting the entire lifetime of the male

Define "oogenesis"

the formation of female egg cells

Define "ova"

singular: ovum; female egg cells

What is the initial cell in oogenesis called?

primary oocyte

Where are primary oocytes found?

found in ovaries in the female reproductive system; ovary is the female gonad

What happens to the two daughter cells from meiotic division in oogenesis?

the two daughter cells simply disintegrate

Define "polar bodies"

the two daughter cells that disintegrate from meiotic division in oogenesis

How often does oogenesis occur?

occurs on a monthly basis, beginning at puberty and ending at menopause

Define "menopause"

end of regular menstrual cycles, an event that usually occurs between the ages of 46 and 54; a single ovum is produced per month

Differentiate between spermatogenesis and oogenesis.

the overall process is about the same, but in oogenesis, the polar bodies disintegrate; four mature sperm are produced, but in oogenesis, only one ovum is produced

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