LLUSM3 Antidepressants
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Created by:
leadclimbsgirl on August 14, 2011
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Description:
Antidepressant mechanisms and common side effects
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25 terms
Terms | Definitions |
|---|---|
 Fluoxetine | Prozac . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . Safe in pregnancy and kids. Long half life. Inhibits p450 |
| Sertraline | Zoloft . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . More GI sfx |
| Paroxetine | Paxil . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . Short half life--withdrawl if not tapered. Inhibits p450 |
| Fluvoxamine | Luvox . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . More NV. Inhibits p450 |
| Citalopram | Celexa . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . Few sfx and least drug interactions. |
| Escitalopram | Lexapro . SSRI . Group SE: Sexual ↓ ND anorexia headache insomnia anxiety akathisia seizures 5HT syndrome. . S-enantiomer to Citalopram. Least sfx. Expensive |
| Venlafaxine | Effexor . . . 5HT and NE reuptake inhibitor (SNRI). Used for depression anxiety and ADHD. SE like SSRI |
| Desvenlafaxine | Pristiq . . . 5HT and NE reuptake inhibitor (SNRI). Metabolite of Venlafaxine. Expensive. SE like SSRI |
| Duloxetine | Cymbalta . . . 5HT and NE reuptake inhibitor (SNRI). Used for depression and nerve pain. SE like SSRI but more dry mouth and C |
| Bupropion | Wellbutrin . . . NE and DA reuptake inhibitor. Used in smoking cessation. Least sexual sfx. Risk of seizures. Do not use in eating disorder patients or with MAOIs |
| Mirtazapine | Remeron . . . A2 Antagonist for refractory depression. SE sedation Weight Gain dizziness tremor dry mouth constipation |
| Trazodone | Desyrel . . . 5HT partial agonist antidepressant. Useful for insomnia. SE ND orthostatic hypotension Priapism |
| Nefazodone | Serzone . . . 5HT partial agonist antidepressant. Useful for insomnia. Black Box warning hepatotoxic. |
| Amitriptyline | Elavil . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . Used for migraines |
| Nortriptyline | Pamelor . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . Less hypotension and sedation |
| Imipramine | Tofranil . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . |
| Desipramine | Norpramin . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . Least sedating. |
| Clomipramine | Anafranil . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . Used for OCD |
| Amoxapine | Asendin . TCA ("dirty" 5HT and NE) . . Related to Loxapin--SE like Antipsychotics (EPS etc) |
| Maprotiline | Ludiomil . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . More seizures Arrhythmias and more fatal in OD |
| Doxepin | Sinequan . TCA ("dirty" 5HT and NE) . Group SE: Sedation Orthostatic hypotension w/ tach Long QT and PR Anticholinergic Weight gain Sexual ↓ Seizures. Lethal in OD . Useful for insomnia |
| Phenelzine | Nardil . Irreversible MAO inhibitor (↑NE DA and 5HT) . Group SE: Serotonin syndrome Hypertensive crisis Drowsiness Weight gain ↓ Sleep and Sex . Good for refractory depression. |
| Isocarboxazid | Marplan . Irreversible MAO inhibitor (↑NE DA and 5HT) . Group SE: Serotonin syndrome Hypertensive crisis Drowsiness Weight gain ↓ Sleep and Sex . Good for refractory depression. |
| Tranylcypromine | Parnate . Irreversible MAO inhibitor (↑NE DA and 5HT) . Group SE: Serotonin syndrome Hypertensive crisis Drowsiness Weight gain ↓ Sleep and Sex . Good for refractory depression. |
| Selegiline | Emsam . Reversible MAO inhibitor. (↑NE DA and 5HT) . Group SE: Serotonin syndrome Hypertensive crisis Drowsiness Weight gain ↓ Sleep and Sex . Good for refractory depression. Transdermal patch |
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