| Term | Definition |
| sadistic | inclined to cruelty; |
| saga | Scandinavian myth; any legend; |
| sagacious | perceptive; shrewd; having insight; |
| sage | person celebrated for wisdom; |
| salacious | lascivious; lustful; |
| salient | prominent; |
| saline | salty; |
| sallow | yellowish; sickly in color; |
| salubrious | healthful; |
| salutary | tending to improve; beneficial; wholesome; |
| salvage | rescue from loss; |
| sanctimonious | expressing ostentatious or hypocritical devoutness; |
| sanction | approve; ratify; |
| sanctuary | refuge; shelter; shrine; holy place; |
| sanguinary | bloody |
| sanguine | hopeful; cheerful; |
| sarcasm | scornful remark; stinging rebuke; |
| sardonic | disdainful; sarcastic; cynical; |
| sartorial | pertaining to tailors; |
| sate | satisfy to the full; cloy; |
| satellite | small body revolving around a larger one; |
| satiate | satisfy fully; |
| satire | form of literature in which irony, sarcasm and ridicule are employed to attack vice and folly; |
| satirical | mocking; |
| saturate | soak thoroughly; |
| saturnine | gloomy; |
| satyr | half-human, half-bestial being in the court of Dionysus, portrayed as wanton and cunning; |
| saunter | stroll slowly; |
| savant | scholar; |
| savor | enjoy; have a distinctive smell, flavor or quality; |
| savory | tasty; pleasing; attractive or agreeable; |
| scabbard | case for the sword blade; sheath; |
| scad | great quantity; |
| scaffold | temporary platform for workers; bracing framework; platform for execution; |
| scale | climb up; ascend; |
| scanty | meager; insufficient; |
| scapegoat | someone who bears the blames of others; |
| scavenge | hunt through discarded materials for usable items; search, especially for food; |
| scenario | plot outline; opera libretto; screenplay; |
| schematic | relating to an outline or diagram; using a system of symbols; |
| schism | (N) division; split; |
| scintilla | least bit; shred; |
| scintillate | (V) sparkle; flash; |
| scoff | (V) mock; ridicule; |
| scotch | stamp out; thwart; hinder; |
| scourge | (N) lash; whip; severe punishment; |
| scruple | fret about; hesitate, especially for ethical reasons; |
| scrupulous | conscientious; extremely thorough; |
| scrutinize | examine closely and critically; |
| scuffle | struggle confusedly; move off in a confused hurry; |
| scurrilous | obscene; indecent; |
| scurry | move briskly; |
| scurvy | despicable; contemptible; |
| scuttle | sink |
| seamy | sordid; unwholesome; |
| sear | char or burn; brand; |
| seasoned | experienced; |
| secession | withdrawal; |
| seclusion | isolation; solitude; |
| secrete | hide away or cache, produce and release a substance into an organism; |
| sect | separate religious body; faction; |
| secular | worldly; temporal; not pertaining to church matters; |
| sedate | composed; grave; |
| sedentary | requiring sitting; |
| sedition | resistance to authority; insubordination; (N) |
| sedulous | diligent; |
| seedy | run-down; decrepit; disreputable; |
| seemly | proper; appropriate; (ADJ) |
| sap | diminish; undermine; |
| seep | ooze; trickle; |
| seethe | be disturbed; boil; |
| seine | net for catching fish; |
| seismic | pertaining to earthquake; |
| semblance | outward appearance; guise; |
| seminal | germinal; influencing future developments; related to seeds or semen; (ADJ) |
| seminary | school for training future ministers, priests, rabbis; secondary school, especially for young women; (N) |
| senility | old age; feeblemindedness of old age; (N) |
| sensitization | process of being made sensitive or acutely responsive to an external agent or substance; |
| sensual | devoted to the pleasures of the senses; carnal; voluptuous; |
| sensuous | pertaining to the physical senses; operating through the senses; |
| sententious | terse; concise; aphoristic; |
| sentient | sensitive; capable of sensation; aware; |
| sentinel | sentry; lookout; |
| septic | putrid; producing putrefaction; |
| sepulcher | tomb; |