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5 Written questions

5 Matching questions

  1. Paracoccidioides brasiliensis Reservoir
  2. Mechanism of Dimorphic Switch
  3. Coccidioides immitis Reservoir
  4. Paracoccidioides brasiliensis Clinical Symptoms
  5. Blastomyces dermatitidis Treatment
  1. a 1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)
  2. b 1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss
  3. c 1. The shift from mold to yeast involves induction of the heat shock response and uncoupling of oxidative phosphorylation
    2. This is followed by shutdown of RNA synthesis
    3. The cells then pass through a metabolically inactive phase
    4. The metabolism in the yeast phase shifts to sulfhydryl compounds
    5. This is reversible and is one of the major virulence factors of these organisms
  4. d 1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission
  5. e 1. Central and S. America
    2. Brazil

5 Multiple choice questions

  1. 1. Not clear what the predominant host response is
    2. Complement, antibody and cell mediated immunity are all involved
  2. Blastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers
  3. 1. Conidia are inhaled and reach the alveoli
    2. The conidia then convert to yeasts
    3. Survive by capturing iron and calcium from the macrophage
    4. Grow within macrophages
    5. Granulomatous inflammation similar to TB (cell-mediated immunity)
  4. Dimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  5. HISTOPLASMOSIS
    1. Asymptomatic (in most persons)
    2. Pneumonia: lesions calcify, which can be seen on chest x-ray (may look similar to tuberculosis)
    3. Disseminated: can occur in almost any organ, especially the LUNG, SPLEEN, LIVER

5 True/False questions

  1. Coccidioides immitis Pathogenesis1. Biopsy of affected tissue: lung, skin
    A. Silver stain or KOH prep
    B. Culture on Sabouraud's agar (warn lab!) 3-4 days
    2. Serology
    3. Skin tests (tests for exposire only)

          

  2. Coccidioides immitis TreatmentOnly for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)

          

  3. Coccidiodes immitis Diagnosis1. Biopsy of affected tissue: lung, skin
    A. Silver stain or KOH prep
    B. Culture on Sabouraud's agar (warn lab!) 3-4 days
    2. Serology
    3. Skin tests (tests for exposire only)

          

  4. Histoplasma capsilatum Immunity1. The main control of this organism is by cell mediated immunity
    -Mainly the T-cell activation of macrophages

    2. Neither B cells or antibody have a significant role

          

  5. Paracoccidioides brasiliensis Morphology1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C

          

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