NAME

Question types


Start with


Question limit

of 30 available terms

Advertisement Upgrade to remove ads
Print test

5 Written questions

5 Matching questions

  1. Coccidioides immitis Pathogenesis
  2. Histoplasma capsilatum Diagnosis
  3. Coccidioides immitis Clinical Symptoms
  4. Coccidioides immitis Immunity
  5. Coccidioides immitis Treatment
  1. a 1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities
  2. b 1. Life long immunity does develop
    2. Conidia can be phagocytosed and killed by PMNs
    3. The endospores cannot be handled until macrophages are activated by T-cells (Th1)
    4. Humoral immunity does not play a role
    5. Complement is not effective at opsonizing C. immitis
  3. c 1. Conidia are inhaled
    2. Once inside host, the conidia change into spherules due to increased temp, lower pH and interactions with phagocytes
    3. The spherule is a "sac" of endospores which are released and lead to new spherules
    4. Proteases released by the spherule are virulence factors
    5. They destroy collagen, elastin and immunoglobulins
  4. d Only for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)
  5. e 1. Lung biopsy
    A. Silver stain specimen
    B. Culture on Sabouraud's agar will reveal hyphae at 25 C, and yeast at 37 C
    2. Serology
    3. Skin test (tests for exposure only)

5 Multiple choice questions

  1. 1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  2. Dimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  3. 1. trimethoprim/sulfamethoxazole (TMP sulfa): 1st choice
    2. itraconazole and amphotericin B
  4. Blastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers
  5. HISTOPLASMOSIS
    1. Asymptomatic (in most persons)
    2. Pneumonia: lesions calcify, which can be seen on chest x-ray (may look similar to tuberculosis)
    3. Disseminated: can occur in almost any organ, especially the LUNG, SPLEEN, LIVER

5 True/False questions

  1. Bastomyces dermatitidis Morphology1. Mississippi river valley extending north to the great lakes
    2. Resides in soil or rotten wood
    3. Respiratory transmission

          

  2. Histoplasma capsulatum Morphology1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

          

  3. Blastomyces dermatitidis DiagnosisBlastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers

          

  4. Paracoccidioides brasiliensis Pathogenesis & Clinical disease1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss

          

  5. Paracoccidioides brasiliensis Clinical Symptoms1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss

          

Create Set