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5 Written questions

5 Matching questions

  1. Blastomyces dermatitidis Treatment
  2. Histoplasma capsulatum Morphology
  3. Coccidioides immitis Morphology
  4. Mechanism of Dimorphic Switch
  5. Coccidioides immitis Treatment
  1. a 1. The shift from mold to yeast involves induction of the heat shock response and uncoupling of oxidative phosphorylation
    2. This is followed by shutdown of RNA synthesis
    3. The cells then pass through a metabolically inactive phase
    4. The metabolism in the yeast phase shifts to sulfhydryl compounds
    5. This is reversible and is one of the major virulence factors of these organisms
  2. b Dimorphic:
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
    3. NO Capsule 9despite name)
    4. Grow in macrophages
  3. c 1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)
  4. d Dimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  5. e Only for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)

5 Multiple choice questions

  1. 1. Primary infection is by inhalation of the conidia
    2. A mixed inflammatory response occurs
    3. The organism then starts to grow as large yeasts with thick double walls
    4. Unlike Histoplasma, these yeasts are extracellular and much larger
  2. 1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission
  3. 1. Diagnosis is made by seeing the yeast with multiple blastoconidia (think of a ship's steering wheel)
    2. Measurement of antibodies have a 95% sensitivity
  4. 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)
  5. 1. Biopsy of affected tissue: lung, skin
    A. Silver stain or KOH prep
    B. Culture on Sabouraud's agar (warn lab!) 3-4 days
    2. Serology
    3. Skin tests (tests for exposire only)

5 True/False questions

  1. Coccidioides immitis ImmunityOnly for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)

          

  2. Paracoccidioides brasiliensis Clinical Symptoms1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss

          

  3. Histoplasma capsilatum Diagnosis1. Lung biopsy
    A. Silver stain specimen
    B. Culture on Sabouraud's agar will reveal hyphae at 25 C, and yeast at 37 C
    2. Serology
    3. Skin test (tests for exposure only)

          

  4. Coccidioides immitis Pathogenesis1. Biopsy of affected tissue: lung, skin
    A. Silver stain or KOH prep
    B. Culture on Sabouraud's agar (warn lab!) 3-4 days
    2. Serology
    3. Skin tests (tests for exposire only)

          

  5. Coccidioides immitis DiseaseCoccidioidomycosis aka "Valley Fever"
    1. Asymptomatic (in most persons)
    2. Pneumonia
    3. Disseminated (<1%): can affect the LUNGS, SKIN, BONES, & MENINGES

    Note: a small percentage of individuals with this infection will develop painful erythematous nodular lesions called erythema nodosum

          

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