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5 Written questions

5 Matching questions

  1. Coccidioides immitis Disease
  2. Blastomyces dermatitidis Immunity
  3. Paracoccidioides brasiliensis Diagnosis
  4. Bastomyces dermatitidis Morphology
  5. Blastomyces dermatitidis Pathogenesis
  1. a 1. Primary infection is by inhalation of the conidia
    2. A mixed inflammatory response occurs
    3. The organism then starts to grow as large yeasts with thick double walls
    4. Unlike Histoplasma, these yeasts are extracellular and much larger
  2. b 1. Diagnosis is made by seeing the yeast with multiple blastoconidia (think of a ship's steering wheel)
    2. Measurement of antibodies have a 95% sensitivity
  3. c 1. Not clear what the predominant host response is
    2. Complement, antibody and cell mediated immunity are all involved
  4. d 1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  5. e Coccidioidomycosis aka "Valley Fever"
    1. Asymptomatic (in most persons)
    2. Pneumonia
    3. Disseminated (<1%): can affect the LUNGS, SKIN, BONES, & MENINGES

    Note: a small percentage of individuals with this infection will develop painful erythematous nodular lesions called erythema nodosum

5 Multiple choice questions

  1. 1. Lung biopsy
    A. Silver stain specimen
    B. Culture on Sabouraud's agar will reveal hyphae at 25 C, and yeast at 37 C
    2. Serology
    3. Skin test (tests for exposure only)
  2. HISTOPLASMOSIS
    1. Asymptomatic (in most persons)
    2. Pneumonia: lesions calcify, which can be seen on chest x-ray (may look similar to tuberculosis)
    3. Disseminated: can occur in almost any organ, especially the LUNG, SPLEEN, LIVER
  3. 1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic
  4. 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)
  5. 1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

5 True/False questions

  1. Coccidioides immitis Reservoir1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission

          

  2. Histoplasma capsilatum Clinical Symptoms1. fevers, sweats, weight loss
    2. in disseminated disease, skin & subcutaneous nodules and mucous membrane ulcerations are not unusual (tongue, larynx)

          

  3. Coccidioides immitis TreatmentCoccidioidomycosis aka "Valley Fever"
    1. Asymptomatic (in most persons)
    2. Pneumonia
    3. Disseminated (<1%): can affect the LUNGS, SKIN, BONES, & MENINGES

    Note: a small percentage of individuals with this infection will develop painful erythematous nodular lesions called erythema nodosum

          

  4. Coccidioides immitis ImmunityCoccidioidomycosis aka "Valley Fever"
    1. Asymptomatic (in most persons)
    2. Pneumonia
    3. Disseminated (<1%): can affect the LUNGS, SKIN, BONES, & MENINGES

    Note: a small percentage of individuals with this infection will develop painful erythematous nodular lesions called erythema nodosum

          

  5. Histoplasma capsilatum Immunity1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)

          

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