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5 Written Questions

5 Matching Questions

  1. Paracoccidioides brasiliensis Clinical Symptoms
  2. Coccidioides immitis Morphology
  3. Blastomyces dermatitidis Pathogenesis
  4. Blastomyces dermatitidis Diagnosis
  5. Paracoccidioides brasiliensis Pathogenesis & Clinical disease
  1. a 1. Primary infection is by inhalation of the conidia
    2. A mixed inflammatory response occurs
    3. The organism then starts to grow as large yeasts with thick double walls
    4. Unlike Histoplasma, these yeasts are extracellular and much larger
  2. b 1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic
  3. c 1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss
  4. d Dimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  5. e 1. The conidia are inhaled and are usually contained and cleared
    2. Chronic disease with pulmonary and/or lymph node involvement
    3. If a person develops pulmonary infection, they develop cough, fever, malaise, weight loss
    4. Can also affect mucous membranes of the mouth, larynx

5 Multiple Choice Questions

  1. 1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission
  2. Blastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers
  3. 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)
  4. Only for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)
  5. 1. The main control of this organism is by cell mediated immunity
    -Mainly the T-cell activation of macrophages

    2. Neither B cells or antibody have a significant role

5 True/False Questions

  1. Histoplasma capsulatum Reservoir1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

          

  2. Coccidioides immitis Disease1. Biopsy of affected tissue: lung, skin
    A. Silver stain or KOH prep
    B. Culture on Sabouraud's agar (warn lab!) 3-4 days
    2. Serology
    3. Skin tests (tests for exposire only)

          

  3. Histoplasma capsilatum Clinical DiseaseHISTOPLASMOSIS
    1. Asymptomatic (in most persons)
    2. Pneumonia: lesions calcify, which can be seen on chest x-ray (may look similar to tuberculosis)
    3. Disseminated: can occur in almost any organ, especially the LUNG, SPLEEN, LIVER

          

  4. Coccidioides immitis Clinical Symptoms1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss

          

  5. Bastomyces dermatitidis MorphologyBlastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers

          

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