SGU Pathophysiology, Pre-Midterm, Immunology (Random)
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21 terms
Terms | Definitions |
|---|---|
 List the cells of the innate immune response | PMNs, monocytes/macrophages, dendritic cells, NK cells, mast cells |
| List the cells of the adaptive immune response | B cells, T cells |
| Briefly describe the MOA for each of the four hypersensitivity reactions | I: Immediate, anaphylactic II: Ab-mediated III: Immune complex-mediated IV: Delayed, cell-mediated |
| In HSRxn I, antigens bind to which Ab? | IgE |
| Which HSRxns involve Abs? | I, II, III |
| In HSRxn II, which Abs bind to 'enemy' cells? | IgG, IgM |
| List the MOAs for HSRxn II | - Complement activation, phagocytosis via opsonization - Ab-dependent cellular cytotoxicity (Fc-mediated) - Bind to normal cell receptors, disrupt functioning |
| List some exemplified HSRxn II pathologies | - Transfusion reactions - Erythroblastosis fetalis - Autoimmune hemolytic anemia - Drug reactions - Inflammation (glomerulonephritis, hyperacute rejection of organ transplant) - Myasthenia gravis - Graves disease - Immune-mediate dermatitis |
| What pattern of IF do HSRxn II pathologies emit? | Linear |
| What pattern of IF do HSRxn III pathologies emit? | Complex (lumpy) |
| In HSRxn III, what Ab is often employed in the creation of an immune complex? | IgG |
| What is the composition of HSRxn III immune complexes? | Ag-Ab (IgG)-complement |
| List some exemplified HSRxn III pathologies | - SLE - RA - PAN - Serum sickness - Arthus reaction - Poststrep glomerulonephritis |
| List the MOAs for HSRxn IV | Activation of Ag-specific T cells, leading to release of cytokines via CD4 cells (> Th1, Th17 activation) |
| List some exemplified HSRcn IV pathologies | - Type I DM - MS - Guillain-Barre - Hashimoto's - GVHD - TB PPD test - Contact dermatitis |
| Which cells become activated and create epitheloid cells helping to form granulomas? | Macrophages |
| What is the simplest assay of lymphocyte enumeration? | CBC with manual differential |
| An absolute lymphocyte count below what value should prompt further investigation? | 2,500 cells/mm3 |
| List some cell markers for the following immune cells: - B cells - T cells - NK cells | B: CD19, CD20, CD21, CD22 T: CD2, CD3, CD4, CD8 NK: CD2, CD16, CD56 |
| What antigen is labeled as a leukocyte common antigen? | CD45 |
| Differentiate between CD45RA and CD45RO | CD45RA is the antigen located on naive T cells while CD45RO is found on memory T cells |
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