List the cells of the innate immune response
PMNs, monocytes/macrophages, dendritic cells, NK cells, mast cells
List the cells of the adaptive immune response
B cells, T cells
Briefly describe the MOA for each of the four hypersensitivity reactions
I: Immediate, anaphylactic
III: Immune complex-mediated
IV: Delayed, cell-mediated
In HSRxn I, antigens bind to which Ab?
Which HSRxns involve Abs?
I, II, III
In HSRxn II, which Abs bind to 'enemy' cells?
List the MOAs for HSRxn II
- Complement activation, phagocytosis via opsonization
- Ab-dependent cellular cytotoxicity (Fc-mediated)
- Bind to normal cell receptors, disrupt functioning
List some exemplified HSRxn II pathologies
- Transfusion reactions
- Erythroblastosis fetalis
- Autoimmune hemolytic anemia
- Drug reactions
- Inflammation (glomerulonephritis, hyperacute rejection of organ transplant)
- Myasthenia gravis
- Graves disease
- Immune-mediate dermatitis
What pattern of IF do HSRxn II pathologies emit?
What pattern of IF do HSRxn III pathologies emit?
In HSRxn III, what Ab is often employed in the creation of an immune complex?
What is the composition of HSRxn III immune complexes?
List some exemplified HSRxn III pathologies
- Serum sickness
- Arthus reaction
- Poststrep glomerulonephritis
List the MOAs for HSRxn IV
Activation of Ag-specific T cells, leading to release of cytokines via CD4 cells (> Th1, Th17 activation)
List some exemplified HSRcn IV pathologies
- Type I DM
- TB PPD test
- Contact dermatitis
Which cells become activated and create epitheloid cells helping to form granulomas?
What is the simplest assay of lymphocyte enumeration?
CBC with manual differential
An absolute lymphocyte count below what value should prompt further investigation?
List some cell markers for the following immune cells:
- B cells
- T cells
- NK cells
B: CD19, CD20, CD21, CD22
T: CD2, CD3, CD4, CD8
NK: CD2, CD16, CD56
What antigen is labeled as a leukocyte common antigen?
Differentiate between CD45RA and CD45RO
CD45RA is the antigen located on naive T cells while CD45RO is found on memory T cells