← Pharmacokinetics Test
5 Written Questions
5 Matching Questions
- What is duration of action?
- What are the two divisions of administration?
- What two types of ingestion are considered their own category?
- Drugs can be absorbed best in a ________ state.
- b 1.) Sublingual - putting a tablet under the tongue and just letting it dissolve (oral by mouth but different absorbed thru oral mucosa to superior vena cava) that goes directly to heart and distributes thru body (totally miss first pass effect)
2.) Rectal - can be used for someone who is very ill and can't swallow (maybe intubated or vomiting a lot)
§ Negative is poor absorption and tissue irritability (lower GI tract not designed to absorb)
□ Not used often but can be used in special situations
- c non-ion
- d 1. Alimentary "Enteral" "GI System - take by mouth and absorbed by gut before it gets into your system
2. Non-Alimentary "Parenteral" - things like inhalation, injection, or transdermal
- e the amount of time drug is above the therapeutic level
5 Multiple Choice Questions
- the study of how a body deals with a drug (what the body does to the drug)
- rapid onset (quick, effective absorption)
because of large surface area between alveoli and capillary bed
- 1. Ability to disintegrate the drug and dissolve into ions (then absorbed thru the membrane)
2. Motility of the GI tract
- False; drug will be moved along too quickly before it has a chance to be absorbed
5 True/False Questions
What are 5 disadvantages of taking medications orally? → 1. For a drug to be absorbed by the gut it needs to be lipid soluble so it can diffuse passively (all drugs can't be lipid soluble)
2. To diffuse readily it should remain in a non-ionized state
3. First-pass effect - Passing by the liver by portal vein before it goes into the general circulation; lose up to 50% of the effective dose at the first pass
4. Visceral blood flow - Affected by things such as age, comorbidites (alter how much is in system)
5. There are some things they can combine to (antibiotic + milk) that makes it totally ineffective
(T/F) It is useful for the drug to move quickly thru the stomach. → False; drug will be moved along too quickly before it has a chance to be absorbed
What is the #1 advantage of oral medications? → ease and convenience
What is the primary goal of taking a drug? → to get enough of that medication into your system to create the desired effect
If a drug is acidic, it passes thru the stomach (readily/slowly). → Enteric coating