Dental prenatal development

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Mlgeisler1  on September 1, 2011

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Dental prenatal development

Embryology
Study of prenatal Dev.
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Definitions

Embryology Study of prenatal Dev.
Prenatal Dev. consist of 3 periods: Preimplantation period - 1st trimester
Embryonic period - 1st trimester
Fetal period - 2nd & 3rd trimester
Primordium Earlist indication of a tissue/organ during prenatal dev.
Meiosis the joining of the ovums chromosomes and the sperms
Mitosis individual cell division
During the First week of the preimplantation period: Fertilization occures in the fallopian tube then travels to the uterus, zygote "fertilized egg" undergoes mitosis while secretion of fluid by the cells w/i the morula, the zygote becomes a blastocyst
Trisomy 21: meiosis faliure, chromosome #21 is present after meiotic division, example down syndrome
Ectopic pregnancy implantation in the fallopian tube
What is the Trophoblast layer in the blastocyst? prenatal support tissue
What is the Embyoblast layer in the blastocyst? Embryo
Embryonic period physiological processes which obbur during this period to change the blastocyst to an embryo: induction,proliferation,differentiation,morphogeneses,maturation
Induction the action of one group of cells to influence the activity of another population of cells which is "competent" to respond. "cell phone analogy"
Proliferation Controlled cellular growth with accompanying accumulation of cellular byproducts: interstitial growth "addition of outter layer",appositional growth "organs"
Differentiation Cells which are identical genetically become quite different structurally and tunctionally;cells change their characteristics and establish a new population:
Cytodifferentiation- cells
Histodifferentiation- tissues
Morphodifferentiation- shapes
Morphogeneses Development of specific tissue morphology. "complex organisms" me vs fish
Maturation attainmint of adult function and size due to proliferation, differentiation, and morphogenesis
During the second week "embryonic period" Blastocyst cells form a bilaminar disc (circular disc of bilayered cells)
Superior epiblast layer- columnar cells
inferior hypoblast layer- cuboidal cells
After the creation of the epiblast/hypoblast layers the bilaminar disc is held in the uterus endometrium between 2 fluid filled cavities: Amniotic cavity- faces epiblast layer (ectoderm)
Yolk sac- faces hypoblast layer (endoerm)
Placenta develops from interations of the trophoblast and endometrical tissues
In the third week "embryonic period" p26 Primitive streak forms w/i the bilaminar disc, some epiblast layer cells "ectoderm" migrat along the streak and turn toward the hypoblast layer locate between the two layers to form a third layer = "mesoderm"
The Embryonic bilaminar disc turns into Trilaminar disc
Trilaminar disc now has three layers Ectoderm-mervous system
Mesoderm-connective tissue "bone"
Endoderm-glands & linings " respitory & digestive linings"
Once the trilaminar disc has three layers it also has ... membranes and ...ends Caudal and cephalic ends
oropharyngeal and cloacal membranes
Development of the CNS begins at the end of the 3 week specialized group of cells turns ectoderm into neuroectoderm
A band of cells extends from caudal to cephalic end
This plate thickens and a groove invaginates centrally
Groove deepens, ends meet, forms neural tube "spinal cord"
CNS development continued: Neural crest cells.. Separate as neural tube fuses migrate cephalically and influence the mesodermal cells in the head and neck area that produce bone, cartilage, pulp, dentin, cimintum, and periodontal ligament.(migrating neuroectoderm)
Treacher Collins Syndrome p29 Full facial development is prevented by an interference in the migratrion of neuroectoderm to the facial region.
Manefesed by: drooped eyelids, malformed ears, hair growth
Ectodermal dysplasia Abnormal dev. of one or more ectodermal structures.
Hereditary etiology
May manifest as abnormalities of teeth, skin, hair,nails,eyes,facial structure,glands
In the fourth week "embryonic period"Disc undergoes folding into an embryo and tissues are placed in their proper positions for fruther dev.
Defferentiation occurs mainly at cephalic end where brain is forming, protruding over the oropharyngeal membrane and cardiac area
Embryo still has three layers
Future GI tract formed by central tube
Developmental disturbances (teratogens) Teratogens may have devastating effects during embryonic period:
rubella virus
alcohol fetal syndrome
radiation
Failure of fusion of neural tube= spina bifida
Fetal Period "9th week to 9th month" p38 Period of maturation
Newly formed tissues and organs begin to function
Dev. disturbances during this period may result from
amniocentesis
systemic tetracycline

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