AN SC 431 Sept 2

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Created by:

amk5359  on September 2, 2011

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AN SC 431 Sept 2

forms of GnRH (3)
1. hypothalamic (GnRH1)
2. midbrain (GnRH2)
3. Telencephalic (GnRH3)
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forms of GnRH (3) 1. hypothalamic (GnRH1)
2. midbrain (GnRH2)
3. Telencephalic (GnRH3)
prostaglandins mode of action autocrine → function within the cells that synthesize them
structure of prostaglandins unsaturated carboxylic acids: 20-C skeleton with 5-member ring
prostaglandins are synthesized from what precursor? Arachidonic Acid
Examples of types of prostaglandins (3) 1. PG I2
2. PG E2
3. PG F2
PG I2 causes... (2) 1. dilation of bronchioles
2. vasodilation
PG E2 causes... (3) 1. uterine contractions during pregnancy
2. GI tract contractions or relaxation
3. bronchiole contraction or dilation

**action depends on specific receptor
PG F2 causes (2) 1. CL regression
2. smooth muscle contractions
prostaglandins & the inflammatory response cause pain/fever
thromboxanes type of PG that stimulates constriction & clotting of platelets. PGI2 has an opposite effect
Aspirin & Prostaglandins Aspirin blocks the cyclooxygenase enzymes → COX involved with conversion of arachidonic acid to PG → acetyl group on aspirin binds & blocks the channel in the enzyme & arachidonic acid cannot enter the active site of the enzyme → blocks synthesis of PGs
(blocks pain response, but also inhibits PG pathway that causes blood clotting)
pheromone chemical produced by an organism that signals its presence to other members of the same species
what organ senses pheromones? Vomeronasal organ (a.k.a. Jacobson's organ) → small sac on either side of the nasal septum
animal behavior associated with pheromone detection Flehmen's response (lip curl)
pheromones can be secreted via... (5) 1. urine
2. feces
3. prepuce (boar)
4. vagina
5. other glands
role of pheromones (3) 1. indicate estrous cycle stage
2. stimulate estrual behavior in female
3. indicate time elapsed since presence of animal

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