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5 Written questions

5 Matching questions

  1. Purine biosynthesis IMP to AMP
  2. Other drugs related to nucleotides and nucleotide metabolism
  3. Nucleoside Phosphorylases
  4. De nove purine biosynthesis is expensive, how much and what do we do
  5. How to take Ribonucleosides from Mono, Di and tri phosphate
  1. a Used for degradation

    Purine Nucleoside Phosphorylase has multiple substrates. Has a stronger affinity for Guo and Ino, and weak affinity for Ado, all are not phosphorylated

    It takes them all to Guanine, hypoxanthine, and adenine pluse a ribose 1 phosphate
  2. b For AMP 8 high energy phosphates, 2 Gln, 1 Gly, 2 Asp

    For GMP 7 high energy phosphates, 3 Gln, 1 Gly, 1 Asp

    Thus we Regulate and use salvage pathways to recycle purines
  3. c IMP uses Aspartate and GTP to add N in place of carboxyl O at top

    Fumarate leaves leaving just NH2 and AMP is formed
  4. d Adenylate Kinase takes ATP and AMP to 2 ADPs

    nucleoside monophosphate kinases take G,C,UMPs plus ATP to ADP plus G,C,UDPs

    nucleoside diphosphate kinases take G,C,UDPs plus ATP to ADP plus G,C,UTPs

    oxidative phosphorylation takes ADP plus Pi to ATP
  5. e Antivirals, acyclovir, Arabinosyladenine araA, for HSV and herpes related viral encephalitis
    Anti retrovirals, AZT, DDC, ddI for HIV
    Anti neoplastics, arabinosylcytosine araC
    Anti Leukemics, 6 mercaptopurin, 6 thiaguanine

5 Multiple choice questions

  1. Clinical use of nucleotide analogs usually is restricted to bases and nucleoside since phosphorylated nucleotides are poorly transported into cells

    They rely on tricking cellular or viral enzymes into phosphorylating nucleosides into metabolically active nucleotide forms, or converting bases into nucleotides vis salvage pathways
  2. Committed Step, and an allosteric enzyme

    Using Aspartate Transcarbamoylase, ATCase takes Carbamoyl Phosphate to N-carbamoyl aspartate adding aspartate
  3. rather than directly inhibiting Thymidylate Synthetase TS is inhibits the cyclical production of the methyl donor N5N10 methylene THF

    It does this by inhibiting the enzyme DHFR dihydrofolate reductase. Stopping the reduction of Dihydrofolate to THF, which is a needed substrate for N5N10 methylene THF
  4. it is similar to dUMP and acts as a suicide inhibitor or thymidylate synthetase TS. This kill rapidly dividing cells Tumors and immune cells
  5. serum urate decraeases
    serum hypoxanthine and xanthine increase, these are more soluble and easily excreted
    Decreases total rate of purine biosynthesis

5 True/False questions

  1. Purine Nucleosid Phosphorylase PNP deficiencyanother rare cause of SCIDS Disorder, since Ino, dIno, Guo and dGuo are strong subtrates of PNP and Ado and dAdo is weak we get a larger build up of dAdo relative to dNTPs

          

  2. Primary Genetic basis of GoutStarting point with PRPP, and activated ribose

    Purine ring is built up step by step while attached to ribose sugar

    forming IMP a nucleotide intermediate that can form either AMP or GMP

          

  3. Purine Biosynthesis OverviewStarting point with PRPP, and activated ribose

    Purine ring is built up step by step while attached to ribose sugar

    forming IMP a nucleotide intermediate that can form either AMP or GMP

          

  4. Lesch-Nyhan Syndromethe base on IMP

          

  5. Anti Leukemicssome discussed earlier
    araC, triphosphate interferes with DNA synthesis

          

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