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Vitamin K dependent factors

II, VII, IX, X

Prodrug converted to active metabolite by CYP2C19

clopidogrel (some people have a polymorphism for CYP2C19)

Treatment of thrombosis in patients with heparin induced thrombocytopenia

argatroban (and stop heparin)

What drug is monitored by measuring the prothrombin time

warfarin

ADP receptor antagonist

clopidogrel

May cause skin necrosis

warfarin

Drug of choice for labor induction

oxytocin

Drug of choice for post partum hemorrhage

oxytocin

Progestin with antiandrogenic activity

drospirenone

Delays premature labor

magnesium sulfate (most popular tocolytic drugs)

May induce insulin resistance

niacin

Absolute contraindication to the use of combined oral contraceptives

heavy smokers > 35 years of age

Delays premature labor

indomethacin -> tocolytic drugs

Antihyperlipidemic that may precipitate gout

niacin

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