5 Written Questions
5 Matching Questions
- maximum effect
- A narrow or low therapeutic index (NTI) is considered a drug where the difference between ED50 and TD50 is
- sound like 2 alpha male see a girl and open the door to let her in
- a ACh receptors are in a _______state of synthesis and degradation for neuromuscular nicotinic receptor structure and properties
- b is the study of drug action. It is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.
- c Imagining why nicotinic cholinergic receptor has 2 alpha unit and requires one molecule of ACh to bind to each, in order to activate the receptor and open the channel
- d <2
- e What is the point at which no further response is achieved regardless of drug concentration. The drug's half maximal effect is referred to as ED50 (effective dose) or EC50 (effective concentration) that results in 50% of a maximal response or effect?
5 Multiple Choice Questions
- ligand binding domain and effector domain
- NTI stands for?
- Name two ligands for cytosolic and nuclear receptor?
- In neuromuscular nicotinic receptor structure and properties, each receptor subunit is translated from mRNA, processed, inserted into the membrane, and anchored via
- For plasma membrane regulatory protein, coupling to adenylate cyclase would lead to?
5 True/False Questions
therapeutic curve → is the ratio of the lethal or toxic doses of that drug in 50% of the test population (LD50 or TD50) over the median minimum effective dose in 50% of the test population (EC50)...i.e. TD50/ED50
4 → How many subunits are neuromuscular nicotinic receptor structure and properties?
endocytosis and lysosomal proteolysis → In neuromuscular nicotinic receptor structure and properties, ACh receptors are degraded via
25 → How many subunits are neuromuscular nicotinic receptor structure and properties?
transcriptional coactivators, corepressors → In Estrogen receptors, dimers formed by ER alpha and beta are associated with other proteins like ________ and ________ which then act to regulate gene expression via binding to DNA.