01_psych MOA update

21 terms by ptatchison 

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amphetamine salts

blocks NE and DA reuptake into presynaptic neuron

methylphenidate

blocks NE and DA reuptake into presynaptic neuron

lisdexamfetamine

active metabolite blocks NE and DA reuptake

alprazolam

binds stereospecific BZ binding site on post-synaptic GABA receptor in CNS

clonazepam

binds BZ subunit on GABA receptor enhancing GABA activity

diazepam

A-type GABA receptor binding reduces neuronal depolarization

lorazepam

GABA receptor agonist

zolpidem

binds BZ receptor subunit of GABA-A receptor complex

prochlorperazine

blocks post synaptic mesolimbic D1 and D2 receptors

amitriptyline HCL

blocks membrane pump mechanism respnsible for absorption of serotonin and norepinephrine in serotonergic and adrenergic neurons; promoting neuronal activity

trazodone HCL

selective inhbition of serotonin reuptake potentiates serotonergic activity in the CNS

citalopram hydrobromide

serotonin reuptake inhibitor with minimal effects on neuronal NE and DA reuptake

fluoxetine HCL

serotonin reuptake inhibitor with minimal effects on neuronal NE and DA reuptake

paroxetine HCL

serotonin reuptake inhibitor with minimal effects on neuronal NE and DA reuptake

sertraline HCL

serotonin reuptake inhibitor with minimal effects on neuronal NE and DA reuptake

duloxetine

potentiates serotonergic and noradrenergic activity in the CNS

venlafaxine

potentiates serotonergic and noradrenergic activity in the CNS

aripiprazole

5-HT1A and D2 partial agonist; 5-HT2A antagonist

quetiapine

5-HT1A, 5-HT2, D1, H1, and adrenergic α 1/2 antagonist

olanzapine

DA and 5-HT2 antagonist

pregabalin

GABA analog; binds alpha-2-delta site of voltage-gated calcium channel in CNS

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