Coagulation & Fibrinolysis (lec 13)

Created by smw88998 

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PT (Prothrombin time) Test

Extrinsic Pathway

aPTT (abnormal partial thromboplastin time) Test

Intrinsic Pathway

TT (Thrombin time) Test

Common Pathway

D-dimer test

shows you had a clot (Factor XIII and Thrombin)

Extrinsic pathway factors involved...

deficiencies in Factors: VII, X, V, II, Fibrinogen

Intrinsic Pathway factors involved...

deficiencies in Factors: XII, HMWK, Prekallikrein, XI, IX, VIII, X, V, II, Fibrinogen

Both pathways (combined abn aPTT & PT

defects in Factors X, V, and II specifically

Factor II

prothrombin, syn in liver, site of gamma-carboxylation by vit K

Factor VIIa

activates Factors X and IX

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