5 Written Questions
5 Matching Questions
- Regardless, of a drug being a weak base or weak acid, the preferred site of drug absorption is where?
- Bioavailability Equation (F)
- In general, dissolution rate correlates better with absorption for drugs that are...
- Absolute Bioavailability
- Fick's Law
- a fraction of the administered dose that reaches systemic circulation relative to an intravenous dose
- b dc/dt = P(C1-C2)
- c F= (AUCpo DOSEiv)/(AUCiv DOSEpo)
- d Small Intestines. the short residence time, small surface area, and low perfusion rate make the small intestines the preferred site of absorption for weak acids as well.
- e highly permeable (highly lipophilic)
5 Multiple Choice Questions
- Orange Book
- Area of study concerned with the formulation, manufacture, stability, and effectiveness of dosage forms
- Specialized transport using a "carrier", but the drug is not moved against a concentration gradient
- Provide correct drug dose, Protect API during storage and from gastric acid, Conceal undesirable taste, Provide rate controlled drug action, Provide optimal drug action from topical sites
- Minimum Effective Concentration; drug concentration that must be achieved for the patient to exhibit adequate response
5 True/False Questions
Passive Diffusion → Area of study concerned with the formulation, manufacture, stability, and effectiveness of dosage forms
Factors that affect drug absorption... → Physiology of the GI tract; Physiochemical characteristics of the drug; and dosage form
Types of Dosage Forms → Solids, Semi-Solids, Inserts, Liquids, Sterile Products, and Novel Delievery Systems
When dissolution is the rate-limiting step in in absorption... → considerations of the proportion of the dose administered that is expected to be absorbed
When rate of absorption is decreased.. → the peak height concentration is lowered and the time of peak occurs later