5 Written Questions
5 Matching Questions
- What is more potent: cyclosporine or tacrolimus?
- what is a patient mechanism of resistance to cyclosporine?
- rho D immunoglobulin
- ***What is tacrolimus currently approved for?
- a P-glycoprotein efflux
- b prevent erythroblastosis fetalis, prevents mom's immune system from interacting with fetus Rh antigen
- c Tacrolimus. 10-100 x
- d similar in structure to myelin protein
reduce attack frequency in MS Pts
- e "Preventing liver and kidney rejections.
Rescue therapy after failure of rejection therapy."
5 Multiple Choice Questions
- IL-1; IL-2; IFN gamma
- il 2 receptor blockers
basiliximab - prevent kidney rejection when used in combo with cyclosporine and corticosteroids. benefit - no myelosupp or have drug interactions.
- no toxic effects
- Potent, reversible, uncompetitive inhibitor of inosine monophosphate --->blocking de novo formation of GMP. (In a nut shell: Blocks guanine synthesis) specific for lymphocytes."
- Because there is no marrow toxicity.
5 True/False Questions
MOA of tacrolimus. → hyperglycemia and doesn't cause hirsutism and gingival hyperplasia like cyclosporine
Cyclophosphamide in high, pulsing doses acts as a ____________________ drug. → Immunosuppresant
Does leflunomide work on resting T-Cells? → No, it's specific for active T cells inhibiting their de novo pathway for making pyrimidines (resting cells use salvage pathway)
***AE of Cyclosporine? → "Reversible nephrotoxicity
50% get disarthria
What should you not intake with cyclosporine? → Inhibits IL2 synthesis